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Table 1 Effect of cimetidine at 9 weeks after subcutaneous inoculation of HSG cells in nude mice

From: Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression

 

Control (saline)

Cimetidine (M/day)

  

10-4

10-2

Injected 1 × 106 cells

9/10 (90%)

4/10 (40%)a

0/10 (0%)b

Mean Tumor Volume, mm3 ± SD (% control)

600.9 ± 12.97 (100%)

58.35 ± 2.67 (9.71%)a

0 (0%)b

  1. A mouse in the control group (1/10) died unexpectedly. Tumor volume was calculated as width2 × length × 0.5.
  2. a P < 0.05 (compared with control).
  3. b P < 0.001.