Figure 2

Desmoglein 2 staining is lower in pancreatic cancer cell membranes compared to normal and chronic pancreatitis tissue. Representative pancreatic tissue sections stained for Dsg2 showed high levels of membrane staining in (A) normal pancreas and (B) chronic pancreatitis (CP) samples. Membrane staining was much weaker in (C) pancreatic adenocarcinoma (PaC) samples. Original magnification x400. (D) Staining intensity of the cell membranes was quantitated (see Methods), categorized into intensity ranges from 0+ to 3+, and the average percentage of cells in each group was determined and represented in a stacked graph for each tissue type (n = 6).