Figure 1

Desmoglein 1 is present in lower levels in pancreatic cancer compared to normal and chronic pancreatitis tissue. Representative pancreatic tissue sections stained for Dsg1 showed high membrane staining in (A) normal pancreas, (B) chronic pancreatitis (CP), and (C) weaker staining in pancreatic adenocarcinoma (PaC) samples. Original magnification x400. (D) Staining intensity of the cell membranes was quantitated (see Methods), categorized into intensity ranges from 0+ to 3+, and the average percentage of cells in each group was determined and represented in a stacked graph for each tissue type (n = 6).