Immunological tolerance and tumor rejection in embryo-aggregated chimeric mice – Lessons for tumor immunity

BMC Cancer

Table 1 Relative chimerism of individual mice versus tumor progression

C57/FVB Mouse Chimera	Coat Chimerism	Hematopoietic Chimerism H2K^b/H2K^q (% Lymphocytes)*	B16-F0 Tumor Weight at Day 18 Post Injection
#1	C57/FVB	56/44	5478 mg^a
#2	C57/FVB	52/48	5802 mg^a
#3	C57/FVB	42/58	4310 mg^a
#4	C57/FVB	57/43	5021 mg^a
#5	C57/FVB	51/49	5724 mg^a
#6	C57/FVB**	36/64	16 mg^b
#7	Only FVB	9/91	No Tumor
#8	Only FVB	7/93	No Tumor^c
#9	Only FVB	7/93	24 mg^b
#10	Only FVB	5/95	14 mg^b,c
#11	Only FVB	8/92	31 mg^b

*- Haplotype frequencies determined for whole blood lymphocytes
**- The black (C57) coat color contribution was minimal. See Figure 2.
^a- Mouse was sacrificed at day 18.
^b- Tumor was surgically removed on day 18 and the mouse continued to be monitored. Resected tumors were largely necrotic at time of resection.
^c- Died of a large peritoneal tumor 8 weeks following s.c. tumor cell injection

ISSN: 1471-2407