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Table 5 Meta-analyses of estimates of pancreatic cancer risk associated with ST for never smokers, using overall population estimates if never smoker estimates are not availablea

From: Systematic review of the relation between smokeless tobacco and cancer of the pancreas in Europe and North America

Meta-analysis

Estimates

Included

Fixed-effect

RR (85% CI)

Random-effects

RR (95% CI)

Heterogeneity

    

Chisquared (d.f.)

I2

P

All studies

2,6,10,13,18,20,23

1.32(0.98–1.77)

1.14(0.67–1.93)

16.06 (6)

62.6

0.013

All preferring snuff to chewingb

2,6,10,13,19,20,26

1.35(0.98–1.86)

1.08(0.64–1.82)

12.31 (6)

51.2

0.055

USA or Canada

2,13,18,20,23

1.08(0.73–1.58)

1.00(0.50–2.02)

11.92 (4)

66.4

0.018

Sweden or Norwayc

6,10

1.78(1.11–2.85)

1.61(0.77–3.34)

1.50 (1)

33.2

0.221

Cohort

2,6,10

1.75 (1.20–2.54)

1.75(1.20–2.54)

1.51 (2)

0.0

0.470

Case-controld

13,18,20,23

0.81(0.49–1.32)

0.84(0.36–1.97)

8.48 (3)

64.6

0.037

Chewing tobacco

18,23

0.97(0.51–1.84)

1.22(0.27–5.55)

4.83 (1)

79.3

0.028

Snuff

6,10,19,26

1.54(1.00–2.37)

1.25(0.64–2.44)

4.54 (3)

33.9

0.209

ST unspecified

2,13,20

1.14(0.70–1.84)

0.89(0.33–2.40)

6.94 (2)

71.2

0.031

Never smoking exclusively

6,10,18,20,23

1.39(0.98–1.99)

1.28(0.71–2.30)

8.80 (4)

54.5

0.066

Excluding Third National Cancer Survey Study [16]

2,6,10,18,20,23

1.46(1.08–1.99)

1.38(0.88–2.15)

9.10 (5)

45.0

0.105

  1. a See Table 3 for the individual study estimates
  2. b Where estimates for both snuff and chewing are available
  3. c There was no significant variation by continent (chisquared = 2.64 on 1 d.f., p = 0.104)
  4. d There was significant variation by study type (chisquared = 6.07 on 1 d.f., p = 0.014)