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Table 3 Results of multivariate Cox regression analysis of disease-free survival (DFS) and overall survival (OS) in 113 breast cancer cases

From: Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis

   Odds ratio (95% CI) Odds ratio (95%CI)
Variable   DFS p value OS p value
Tumor size pT1 1.0 (referent) 0.0347 1.0 (referent) 0.1299
  pT2-4 2.91 (1.08–7.82)   2.08 (0.81–5.39)  
Lymph node metastasis Negative 1.0 (referent) 0.0007 1.0 (referent) 0.0107
  Positive 5.43(2.03–14.49)   3.32 (1.32–8.32)  
ER Positive 1.0 (referent) 0.8809 1.0 (referent) 0.3942
  Negative 1.07 (0.46–2.47)   1.50 (0.59–3.83)  
PgR Positive 1.0 (referent) 0.4759 1.0 (referent) 0.0643
  Negative 1.34 (0.60–3.02)   2.27 (0.95–5.39)  
c-erbB-2 Negative 1.0 (referent) 0.6208 1.0 (referent) 0.7099
  Positive 1.19 (0.59–2.39)   1.16 (0.53–2.56)  
p53 Negative 1.0 (referent) 0.5545 1.0 (referent) 0.5544
  Positive 1.25 (0.60–2.62)   1.30 (0.55–3.07)  
Histological grade I and II 1.0 (referent) 0.2145 1.0 (referent) 0.1295
  III 1.55 (0.78–3.12)   1.81 (0.84–3.91)  
Nitrotyrosine formation Low 1.0 (referent) 0.1247 1.0 (referent) 0.0669
  High 2.03 (0.82–5.02)   2.76 (0.93–8.20)  
CXCR4 (cytoplasm) Negative 1.0 (referent) 0.0465 1.0 (referent) 0.0263
  Positive 2.08 (1.01–4.26)   2.59 (1.12–6.02)  
CXCR4 (nucleus) Negative 1.0 (referent) 0.7341 1.0 (referent) 0.9446
  Positive 1.15 (0.52–2.55)   1.03 (0.45–2.39)  
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