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Table 3 Results of multivariate Cox regression analysis of disease-free survival (DFS) and overall survival (OS) in 113 breast cancer cases

From: Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis

  

Odds ratio (95% CI)

Odds ratio (95%CI)

Variable

 

DFS

p value

OS

p value

Tumor size

pT1

1.0 (referent)

0.0347

1.0 (referent)

0.1299

 

pT2-4

2.91 (1.08–7.82)

 

2.08 (0.81–5.39)

 

Lymph node metastasis

Negative

1.0 (referent)

0.0007

1.0 (referent)

0.0107

 

Positive

5.43(2.03–14.49)

 

3.32 (1.32–8.32)

 

ER

Positive

1.0 (referent)

0.8809

1.0 (referent)

0.3942

 

Negative

1.07 (0.46–2.47)

 

1.50 (0.59–3.83)

 

PgR

Positive

1.0 (referent)

0.4759

1.0 (referent)

0.0643

 

Negative

1.34 (0.60–3.02)

 

2.27 (0.95–5.39)

 

c-erbB-2

Negative

1.0 (referent)

0.6208

1.0 (referent)

0.7099

 

Positive

1.19 (0.59–2.39)

 

1.16 (0.53–2.56)

 

p53

Negative

1.0 (referent)

0.5545

1.0 (referent)

0.5544

 

Positive

1.25 (0.60–2.62)

 

1.30 (0.55–3.07)

 

Histological grade

I and II

1.0 (referent)

0.2145

1.0 (referent)

0.1295

 

III

1.55 (0.78–3.12)

 

1.81 (0.84–3.91)

 

Nitrotyrosine formation

Low

1.0 (referent)

0.1247

1.0 (referent)

0.0669

 

High

2.03 (0.82–5.02)

 

2.76 (0.93–8.20)

 

CXCR4 (cytoplasm)

Negative

1.0 (referent)

0.0465

1.0 (referent)

0.0263

 

Positive

2.08 (1.01–4.26)

 

2.59 (1.12–6.02)

 

CXCR4 (nucleus)

Negative

1.0 (referent)

0.7341

1.0 (referent)

0.9446

 

Positive

1.15 (0.52–2.55)

 

1.03 (0.45–2.39)

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