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Table 5 Gene name, description, and function of the 14-gene prognostic signature and the overlap with previously reported signatures

From: Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature

Gene Paik et al van't Veer et al Dai et al Gene Description Gene Function
BUB1    x BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) cell cycle
CCNB1 x    cyclin B1 regulation of cell cycle
CENPA   x x centromere protein A, 17kDa chromosome organization and biogenesis (sensu Eukarya), nucleosome assembly
DC13   x   DC13 protein assembly of cytochrome oxidase
DIAPH3   x x diaphanous homolog 3 (Drosophila) actin cytoskeleton organization and biogenesis
MELK   x   maternal embryonic leucine zipper kinase protein amino acid phosphorylation, ATP binding
MYBL2 x    v-myb myeloblastosis viral oncogene homolog (avian)-like 2 anti-apoptosis, regulation of cell cycle, development
ORC6L   x x origin recognition complex, subunit 6 homolog-like (yeast) DNA replication
PKMYT1    x membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase protein amino acid phosphorylation, regulation of cyclin dependent protein kinase activity
PRR11    x proline rich 11 E2F transcription factor taget gene, regulation of cell cycle
RACGAP1    x Rac GTPase activating protein 1 electron transport
RFC4   x   replication factor C (activator 1) 4, 37kDa DNA replication
TK1    x thymidine kinase 1, soluble DNA metabolism
UBE2S    x ubiquitin-conjugating enzyme E2S ubiquitin cycle