|  | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
Study | Variable | Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value |
Training set (untreated set) | 14-gene signature | 2.48 (1.42–4.32) | 0.001 | 2.00 (1.05–3.83) | 0.036 |
 | Age | 1.08 (1.05–1.11) | <0.0001 | 1.08 (1.05–1.11) | <.0001 |
 | Tumor size | 1.42 (0.85–2.39) | 0.181 | 1.00 (0.56–1.78) | 0.994 |
 | Grade 2 | 1.41 (0.83–2.40) | 0.210 | 1.44 (0.80–2.59) | 0.223 |
 | Grade 3 | 0.80 (0.11–5.93) | 0.830 | 1.15 (0.15–9.08) | 0.897 |
Validation set (untreated set) | 14-gene signature | 2.26 (1.51–3.38) | <0.0001 | 1.97 (1.28–3.04) | 0.002 |
 | Age | 1.06 (1.05–1.08) | <0.0001 | 1.06 (1.04–1.08) | <.0001 |
 | Tumor size | 1.61 (1.27–2.03) | <0.0001 | 1.07 (0.84–1.38) | 0.571 |
 | Grade 2 | 2.42 (1.35–4.34) | 0.003 | 1.47 (0.80–2.70) | 0.218 |
 | Grade 3 | 2.95 (1.54–5.63) | 0.001 | 1.32 (0.65–2.66) | 0.442 |