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Table 3 Univariate and multivariate Cox proportional analyses of overall survival

From: Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature

   Univariate analysis Multivariate analysis
Study Variable Hazard ratio
(95% CI)
p-value Hazard ratio
(95% CI)
p-value
Training set
(untreated set)
14-gene signature 2.48 (1.42–4.32) 0.001 2.00 (1.05–3.83) 0.036
  Age 1.08 (1.05–1.11) <0.0001 1.08 (1.05–1.11) <.0001
  Tumor size 1.42 (0.85–2.39) 0.181 1.00 (0.56–1.78) 0.994
  Grade 2 1.41 (0.83–2.40) 0.210 1.44 (0.80–2.59) 0.223
  Grade 3 0.80 (0.11–5.93) 0.830 1.15 (0.15–9.08) 0.897
Validation set
(untreated set)
14-gene signature 2.26 (1.51–3.38) <0.0001 1.97 (1.28–3.04) 0.002
  Age 1.06 (1.05–1.08) <0.0001 1.06 (1.04–1.08) <.0001
  Tumor size 1.61 (1.27–2.03) <0.0001 1.07 (0.84–1.38) 0.571
  Grade 2 2.42 (1.35–4.34) 0.003 1.47 (0.80–2.70) 0.218
  Grade 3 2.95 (1.54–5.63) 0.001 1.32 (0.65–2.66) 0.442
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