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Table 2 Univariate and multivariate Cox proportional analyses of distant-metastasis-free survival

From: Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature

   Univariate analysis Multivariate analysis
Study Variable Hazard ratio
(95% CI)
p-value Hazard ratio
(95% CI)
p-value
Training set
(untreated set)
14-gene signature 4.34 (1.86–10.1) 0.001 3.16 (1.27–7.87) 0.014
  Age 1.00 (0.97–1.03) 0.853 1.00 (0.97–1.03) 0.956
  Tumor size 1.91 (1.00–3.63) 0.050 1.41 (0.68–2.91) 0.353
  Grade 2 2.21 (1.05–4.70) 0.038 1.45 (0.65–3.22) 0.360
  Grade 3 1.72 (0.22–13.3) 0.604 0.72 (0.09–6.00) 0.759
Validation set
(untreated set)
14-gene signature 4.71 (2.33–9.51) <0.0001 4.02 (1.91–8.44) 0.0002
  Age 1.03 (1.00–1.05) 0.024 1.02 (0.99–1.04) 0.193
  Tumor size 1.75 (1.25–2.46) 0.001 1.37 (0.95–2.00) 0.092
  Grade 2 2.43 (1.10–5.40) 0.029 1.25 (0.55–2.87) 0.592
  Grade 3 3.01 (1.23–7.39) 0.016 1.11 (0.43–2.87) 0.833
Tam-treated set 14-gene signature 3.61 (0.86–15.1) 0.079 3.50 (0.58–21.2) 0.172
  Age 1.04 (0.98–1.10) 0.241 1.06 (0.98–1.14) 0.166
  Tumor grade 1.50 (0.50–4.49) 0.468 NA NA