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Figure 7 | BMC Cancer

Figure 7

From: Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

Figure 7

Silencing of MEK1 or MEK2 expression restrains activating phosphorylation of the MAP kinases ERK1/ERK2. HCT116 cells were infected with lentiviruses encoding shRNAs to MEK1 or MEK2 gene. The expression of MEK1/MEK2, ERK1/ERK2 and phospho-ERK1/2 was measured by immunoblotting at day 1 as described in the legend of Figure 6. NS, non-silencing inactive MEK1 shRNA.

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