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Figure 3 | BMC Cancer

Figure 3

From: Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

Figure 3

Constitutive activation of MEK1 or MEK2 promotes tumor metastasis to the liver and lung. (A) Motility of IEC-6 cell populations was assayed by measuring their migration through porous membranes coated with collagen type I in modified Boyden chambers. Cells on the bottom side of the membrane were fixed and stained. (B) Invasiveness of IEC-6 cell populations was assayed as in A except that membranes were coated with a layer of Matrigel extracellular matrix proteins. Results are expressed as fold-increase relative to vector-infected cells. (C) Incidence of metastasis following orthotopic transplantation of IEC-6 cell populations in the caecum of mice. (D) Representative pictures of lung metastases derived from intestinal tumors expressing activated MEK1 or MEK2.

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BMC Cancer

ISSN: 1471-2407

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