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Table 2 Analysis of association between combinations of genotypes and risk for colorectal cancer, in the entire study population.

From: Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study

A. Encoding of theoretical combinations of genotypes
Patterns of genotypic combinations Effect on colorectal cancer
PTGS1 c.639C>A PLA2G2A c.435+230C>T PPARG c.1431C>T IL8 c.-352T>A MTHFR c.1286A>C  
0 0 0 0 0 Null or very weak (reference pattern)
0 1 or 2 1 or 2 0 0 Protective (protective patterns) *
1 or 2 0 0 1 or 2 1 or 2 Predisposing (predisposing patterns)
Other genotypes Average (mixed patterns)
B. Analysis of observed combination of genotypes association with colorectal cancer (n = 2144, adjusted by sex and age)
Patterns of genotypic combinations Controls Patients OR (95% CI) P-value**  
Reference pattern 95 (8.5%) 63 (6.2%) 1.00   
Protective patterns 7 (0.6%) 4 (0.4%) 0.86 (0.24–3.06) 0.8180  
Mixed patterns 978 (87.2%) 890 (87.0%) 1.37 (0.98–1.90) 0.0602  
Predisposing patterns 41 (3.7%) 66 (6.4%) 2.65 (1.58–4.42) 0.0005  
Reference and mixed patterns 1080 (96.3%) 957 (93.5%) 1.00   
Predisposing patterns 41 (3.7%) 66 (6.5%) 1.97 (1.31–2.97) 0.0009  
  1. * These patterns were inferred from the identification of the predisposing patterns.
  2. ** Observed associations in bold met a false discovery rate criterion of < 0.1.