Table 2 Analysis of association between combinations of genotypes and risk for colorectal cancer, in the entire study population.
A. Encoding of theoretical combinations of genotypes | |||||
|---|---|---|---|---|---|
Patterns of genotypic combinations | Effect on colorectal cancer | ||||
PTGS1 c.639C>A | PLA2G2A c.435+230C>T | PPARG c.1431C>T | IL8 c.-352T>A | MTHFR c.1286A>C | Â |
0 | 0 | 0 | 0 | 0 | Null or very weak (reference pattern) |
0 | 1 or 2 | 1 or 2 | 0 | 0 | Protective (protective patterns) * |
1 or 2 | 0 | 0 | 1 or 2 | 1 or 2 | Predisposing (predisposing patterns) |
Other genotypes | Average (mixed patterns) | ||||
B. Analysis of observed combination of genotypes association with colorectal cancer (n = 2144, adjusted by sex and age) | |||||
Patterns of genotypic combinations | Controls | Patients | OR (95% CI) | P-value** | Â |
Reference pattern | 95 (8.5%) | 63 (6.2%) | 1.00 | Â | Â |
Protective patterns | 7 (0.6%) | 4 (0.4%) | 0.86 (0.24–3.06) | 0.8180 |  |
Mixed patterns | 978 (87.2%) | 890 (87.0%) | 1.37 (0.98–1.90) | 0.0602 |  |
Predisposing patterns | 41 (3.7%) | 66 (6.4%) | 2.65 (1.58–4.42) | 0.0005 |  |
Reference and mixed patterns | 1080 (96.3%) | 957 (93.5%) | 1.00 | Â | Â |
Predisposing patterns | 41 (3.7%) | 66 (6.5%) | 1.97 (1.31–2.97) | 0.0009 |  |