Relationship between c-Met and DR5 expression in human embryonal CNS tumors. A. Quantitative reverse transcription-PCR results showing the expression levels of c-Met and DR5 relative to actin in 18 snap-frozen tissues samples. The expression of c-Met and DR5 in all samples was calculated in relation to DAOY expression. B. We assigned tumors to either high (upper third), median (middle third) and low (lowest third) c-Met expression or TRAIL expression (N = 6 per group). Of the 6 tumors expressing high c-Met (H-cMet), 50% expressed high DR5. Of the 6 tumors expressing low c-Met (L-cMet), 50% expressed low level of DR5. The correlation between c-Met expression and DR5 expression is 0.4 (P = 0.06, Log Pearson analysis).