Skip to main content

Table 6 Odds ratios (OR) and 95% confidence intervals (CI) estimating the association between ESR1 rs9340799 and endometrial cancer by subgroups of other endometrial cancer risk factors

From: Estrogen receptor alpha gene polymorphism and endometrial cancer risk – a case-control study

   ORs and CIs for rs9340799 genotypea  
Covariate Case/contl A/A A/G GG P for interaction
Use of oral low potency estrogen (estriol)
Never 533/1213 1 (ref) 0.79 (0.64–0.99) 0.55 (0.37–0.81)  
Ever 127/153 1.77 (1.20–2.61) 1.28 (0.86–1.92) 1.52 (0.74–3.15) 0.50
BMI (kg/m2)      
< 25 265/698 1 (ref) 0.83 (0.61–1.13) 0.62 (0.37–1.03)  
25–28 136/387 1.01 (0.71–1.45) 0.70 (0.48–1.02) 0.59 (0.27–1.27)  
> 28 261/283 2.90 (2.05–4.11) 2.05 (1.46–2.87) 1.39 (0.80–2.43) p = 0.93
Smokingb      
Never 434/783 1 (ref) 0.84 (0.05–1.08) 0.51 (0.33–0.80)  
Ever 228/585 0.75 (0.56–1.00) 0.50 (0.37–0.68) 0.59 (0.35–0.98) p = 0.17
Use of combined oral contraceptives
Never 500/863 1 (ref) 0.86 (0.68–1.09) 0.58 (0.38–0.87)  
Ever 162/505 0.63 (0.46–0.87) 0.38 (0.27–0.54) 0.43 (0.24–0.78) p = 0.19
Parity      
0 childbirths 94/137 1 (ref) 0.78 (0.44–1.38) 0.44 (0.16–1.24)  
1 childbirth 135/251 0.69 (0.41–1.18) 0.62 (0.37–1.04) 0.51 (0.23–1.11)  
≥ 2 childbirths 433/980 0.62 (0.39–0.96) 0.45 (0.29–0.70) 0.37 (0.21–0.65) p = 0.88
At at menopause (years)
< 50 157/447 1 (ref) 0.81 (0.53–1.20) 0.51 (0.25–1.05)  
50–51.5 125/393 0.98 (0.64–1.48) 0.68 (0.45–1.04) 0.79 (0.40–1.55)  
> 51.5 294/470 1.75 (1.23–2.51) 1.48 (1.03–2.12) 0.95 (0.54–1.66) p = 0.72
Age at last birth (years, among parous only)
≤ 27 209/364 1 (ref) 0.66 (0.46–0.97) 0.75 (0.40–1.41)  
27.5–32.5 194/452 0.75 (0.52–1.09) 0.53 (0.36–0.79) 0.33 (0.17–0.64)  
≥ 33 165/415 0.55 (0.37–0.81) 0.52 (0.35–0.77) 0.39 (0.20–0.75) p = 0.46
Family history of endometrial cancerc
No 564/1262 1 (ref) 0.78 (0.63–0.97) 0.63 (0.44–0.90)  
Yes 65/67 2.56 (1.47–4.46) 1.28 (0.76–2.18) 1.48 (0.39–5.66) p = 0.51
  1. a Analyses were conditioned on age, hormone use for more than two years, and diabetes mellitus b Smoking is defined as having smoked at least 100 cigarettes or having smoked regularly for at least one year c Family history is defined as having a mother or a sister with endometrial cancer.
\