Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression

BMC Cancer

Table 2 HIF-1α expression in non-metastatic (N0/M0), lymphogenously-metastatic (N+) and haematogenously-metastatic (M+) colorectal carcinomas

		cytoplasmatic HIF-1α expression			nuclear HIF-1α expression
metastatic status	n	weak	mod	strong	weak	mod	strong
N0/M0	38	5	12	21	8	6	24
N+	21	5	6	10	3	10	10
M+	33	6	11	16	3	17	13

With respect to the T status all investigated tumors were T3 and moderately differentiated (G2). No statistical significance between cytoplasmtic or nuclear HIF-1α expression and the metastatic status was observed.

ISSN: 1471-2407