Figure 1From: Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression HIF-1α expression in precursor lesions of colorectal carcinogenesis. In normal mucosa (A), HP (B) and TA-LGD (C) specific HIF-1α expression was not seen. SSA and TA-HGD showed a strong diffusely perinuclear (D1 and E1) and on the surface crypts focally nuclear (D2 and E2) HIF-1α immunopositivity.Back to article page