Table 1 TP53 Arg72Pro and PIN3 Ins16bp genotypic and allelic frequencies. Association with familial and sporadic breast cancer risk.
TP53 Polymorphism | Genotype | Positive FH Cases | Controls | OR* (95% CI) | Sporadic Cases | Controls | OR* (95% CI) |
|---|---|---|---|---|---|---|---|
Arg72Pro | Â | Â | Â | Â | Â | Â | Â |
| Â | Arg/Arg | 39 (53.4) | 256 (59.0) | Reference | 98 (56.0) | 124 (58.5) | Reference |
|  | Arg/Pro | 25 (34.2) | 142 (32.7) | 1.19 (0.68–2.08) | 61 (34.9) | 70 (33.0) | 1.26 (0.79–2.02) |
|  | Pro/Pro | 9 (12.3) | 36 (8.3) | 1.58 (0.68–3.67) | 16 (9.1) | 18 (8.5) | 1.35 (0.63–2.88) |
Alleles | Â | Â | Â | Â | Â | Â | Â |
| Â | Arg | 103 (70.5) | 654 (75.3) | Reference | 257 (73.4) | 318 (75.0) | Reference |
|  | Pro | 43 (29.5) | 214 (24.7) | 1.28 (0.85–1.91) | 93 (26.6) | 106 (25.0) | 1.09 (0.78–1.52) |
PIN3 Ins16bp | Â | Â | Â | Â | Â | Â | Â |
| Â | A1A1 | 46 (65.7) | 299 (68.0) | Reference | 122 (63.9) | 147 (68.1) | Reference |
|  | A1A2 | 15 (21.4) | 130 (29.5) | 0.80 (0.43–1.49) | 56 (29.3) | 65 (30.1) | 1.07 (0.67–1.70) |
|  | A2A2 | 9 (12.9) | 11 (2.5) | 4.40 (1.60–12.0) | 13 (6.8) | 4 (1.9) | 3.88 (1.18–12.8) |
Alleles | Â | Â | Â | Â | Â | Â | Â |
| Â | A1 | 107 (76.4) | 728 (82.7) | Reference | 300 (78.5) | 359 (83.1) | Reference |
|  | A2 | 33 (23.6) | 152 (17.3) | 1.48 (0.94–2.31) | 82 (21.5) | 73 (16.9) | 1.34 (0.93–1.94) |