|
TP53 Polymorphism
|
Genotype
|
Positive FH Cases
|
Controls
|
OR* (95% CI)
|
Sporadic Cases
|
Controls
|
OR* (95% CI)
|
|---|
|
Arg72Pro
| | | | | | | |
| |
Arg/Arg
|
39 (53.4)
|
256 (59.0)
|
Reference
|
98 (56.0)
|
124 (58.5)
|
Reference
|
| |
Arg/Pro
|
25 (34.2)
|
142 (32.7)
|
1.19 (0.68–2.08)
|
61 (34.9)
|
70 (33.0)
|
1.26 (0.79–2.02)
|
| |
Pro/Pro
|
9 (12.3)
|
36 (8.3)
|
1.58 (0.68–3.67)
|
16 (9.1)
|
18 (8.5)
|
1.35 (0.63–2.88)
|
|
Alleles
| | | | | | | |
| |
Arg
|
103 (70.5)
|
654 (75.3)
|
Reference
|
257 (73.4)
|
318 (75.0)
|
Reference
|
| |
Pro
|
43 (29.5)
|
214 (24.7)
|
1.28 (0.85–1.91)
|
93 (26.6)
|
106 (25.0)
|
1.09 (0.78–1.52)
|
|
PIN3 Ins16bp
| | | | | | | |
| |
A1A1
|
46 (65.7)
|
299 (68.0)
|
Reference
|
122 (63.9)
|
147 (68.1)
|
Reference
|
| |
A1A2
|
15 (21.4)
|
130 (29.5)
|
0.80 (0.43–1.49)
|
56 (29.3)
|
65 (30.1)
|
1.07 (0.67–1.70)
|
| |
A2A2
|
9 (12.9)
|
11 (2.5)
|
4.40 (1.60–12.0)
|
13 (6.8)
|
4 (1.9)
|
3.88 (1.18–12.8)
|
|
Alleles
| | | | | | | |
| |
A1
|
107 (76.4)
|
728 (82.7)
|
Reference
|
300 (78.5)
|
359 (83.1)
|
Reference
|
| |
A2
|
33 (23.6)
|
152 (17.3)
|
1.48 (0.94–2.31)
|
82 (21.5)
|
73 (16.9)
|
1.34 (0.93–1.94)
|
- * OR adjusted for age (logistic regression analysis)
- FH – family history; OR – odds ratio; CI – confidence interval
