Skip to main content

Table 1 TP53 Arg72Pro and PIN3 Ins16bp genotypic and allelic frequencies. Association with familial and sporadic breast cancer risk.

From: Importance of TP53 codon 72 and intron 3 duplication 16bppolymorphisms in prediction of susceptibility on breast cancer

TP53 Polymorphism Genotype Positive FH Cases Controls OR* (95% CI) Sporadic Cases Controls OR* (95% CI)
Arg72Pro        
  Arg/Arg 39 (53.4) 256 (59.0) Reference 98 (56.0) 124 (58.5) Reference
  Arg/Pro 25 (34.2) 142 (32.7) 1.19 (0.68–2.08) 61 (34.9) 70 (33.0) 1.26 (0.79–2.02)
  Pro/Pro 9 (12.3) 36 (8.3) 1.58 (0.68–3.67) 16 (9.1) 18 (8.5) 1.35 (0.63–2.88)
Alleles        
  Arg 103 (70.5) 654 (75.3) Reference 257 (73.4) 318 (75.0) Reference
  Pro 43 (29.5) 214 (24.7) 1.28 (0.85–1.91) 93 (26.6) 106 (25.0) 1.09 (0.78–1.52)
PIN3 Ins16bp        
  A1A1 46 (65.7) 299 (68.0) Reference 122 (63.9) 147 (68.1) Reference
  A1A2 15 (21.4) 130 (29.5) 0.80 (0.43–1.49) 56 (29.3) 65 (30.1) 1.07 (0.67–1.70)
  A2A2 9 (12.9) 11 (2.5) 4.40 (1.60–12.0) 13 (6.8) 4 (1.9) 3.88 (1.18–12.8)
Alleles        
  A1 107 (76.4) 728 (82.7) Reference 300 (78.5) 359 (83.1) Reference
  A2 33 (23.6) 152 (17.3) 1.48 (0.94–2.31) 82 (21.5) 73 (16.9) 1.34 (0.93–1.94)
  1. * OR adjusted for age (logistic regression analysis)
  2. FH – family history; OR – odds ratio; CI – confidence interval