Figure 5
From: Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance
Effects of cyclosporin A on drug uptake and drug sensitivity in co-cultured control and drug-resistant cells. Cells selected to dose 9 or dose 12 levels of doxorubicin, epirubicin, paclitaxel, or docetaxel were pre-treated with or without 5 μM cyclosporin A and monitored for uptake of paclitaxel or doxorubicin relative to MCF-7CC cells (panel A). Identical cells pre-treated with or without 5 μM cyclosporin A were also assessed for their sensitivity to doxorubicin or paclitaxel using a clonogenic assay (panel B).