Figure 2
From: Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance
Relationship between drug uptake and drug resistance in various drug-resistant cell lines. Sensitivity of MCF-7TAX-2, MCF-7TXT, MCF-7DOX-2, and MCF-7EPI cells (at various selection doses) to doxorubicin, epirubicin, or paclitaxel was measured using a clonogenic assay and compared to MCF-7CC cells to determine fold drug resistance (the resistance factor). Uptake of doxorubicin, epirubicin, and paclitaxel was also measured in the drug-resistant cell lines and expressed relative to uptake into MCF-7CC cells. The relationships between doxorubicin (A), epirubicin (B), or paclitaxel (C) uptake and fold resistance to various drugs in the cell lines were then plotted.