Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population

Table 1 Clinical characteristics and tumor parameters of patients according to LCT 13910 C/T and CaSR A986S genotypes

	LCT 13910 C/T genotypes			CaSR A986S genotypes
	TT + TC (n = 125)	CC (n = 90)	p value	AA + AS (n = 200)	SS (n = 15)	p value
Age at the diagnosis (year) (mean ± SD)	60 ± 11	61 ± 10	0.54	61 ± 10	62 ± 13	0.64
Male/female (case number)	66/59	54/36	0.29	112/88	8/7	0.84
Tumor location (case number)			0.71^a			0.40^a
Rectum	69	52		111	10
Left colon	27	17		41	3
Right colon	29	21		48	2
TNM classification (case number)
T1	0	2	0.54^b	2	0	0.22^b
T2	25	13		37	1
T3	74	60		125	9
T4	26	15		36	5
N0	36	25	0.87^c	54	7	0.10^c
N1	58	43		96	5
N2	31	22		50	3
M0	88	66	0.49	143	11	0.88
M1	38	23		57	4
AJCC stages (case number)			0.87^d			0.10^d
I	10	6		15	1
IIA	13	10		20	3
IIB	13	9		19	3
IIIA	9	4		13	0
IIIB	26	20		44	2
IIIC	16	18		32	2
IV	38	23		57	4
Serum calcium (mmol/L), (mean ± SD)	2.39 ± 0.12	2.39 ± 0.11	0.85	2.39 ± 0.11	2.39 ± 0.16	0.91
Normal range (2.2–2.6)
Female	2.41 ± 0.11	2.36 ± 0.14	0.038^e	2.39 ± 0.11	2.43 ± 0.18	0.42
Male	2.37 ± 0.12	2.39 ± 0.11	0.23	2.39 ± 0.11	2.35 ± 0.15	0.37
Adjusted serum calcium (mmol/L), (mean ± SD)	2.30 ± 0.11	2.30 ± 0.13	0.89	2.29 ± 0.11	2.35 ± 0.17	0.13
Normal range (2.09–2.54)
Female	2.31 ± 0.12	2.29 ± 0.11	0.31	2.29 ± 0.11	2.40 ± 0.19	0.036^e
Male	2.29 ± 0.10	2.31 ± 0.14	0.54	2.29 ± 0.12	2.31 ± 0.14	0.89
Serum CEA (ng/mL), [median (interquartile range)]	3.33(25.16)	3.41(13.61)	0.79	3.34(16.13)	3.01(90.77)	0.89
Normal range (< 4.3)
Serum CA19-9 (U/mL), [median (interquartile range)]	11.15(92.09)	7.21(26.53)	0.59	9.77(42.66)	6.88(214.75)	0.98
Normal range (< 39)
Serum AFP (ng/mL), [median (interquartile range)]	3.81(2.23)	3.43(3.05)	0.58	3.57(2.33)	3.57(6.52)	0.94
Normal range (< 13.6)

^aP value designates the association for rectum vs. other tumor site
^bP value designates the association for T1+T2 vs. T3+T4 stages
^cP value designates the association for N0 vs. N1+N2 stages
^dP value designates the association for I-II vs. III-IV stages
^eThe association did not remain significant after adjusting for multiple testing
Detailed data were available only for 215 CRC patients

ISSN: 1471-2407