Voluntary exercise inhibits intestinal tumorigenesis in Apc Min/+mice and azoxymethane/dextran sulfate sodium-treated mice

Table 2 Effect of voluntary exercise on serum IGF-1 and IGFBP-3 levels in Apc ^Min/+ mice on high-fat diet^a

Groups (N)	IGF-1 levels (ng/ml)	IGFBP-3 levels (ng/ml)	Molar ratio of IGF-1 to IGFBP-3^b
Control (19)	312.4 ± 14.5	53.5 ± 2.8	22.8 ± 1.6
Exercise (19)	283.0 ± 18.8	63.9 ± 3.4*	16.8 ± 1.6**

^a Samples from Experiment 2. IGF-1 and IGFBP-3 levels were determined in serum samples by EIA. Values are mean ± SE of the number of samples (N) analyzed.
^bMolar ratio was calculated by 3.7 × IGF-1 (ng/ml)/IGFBP-3 (ng/ml) due to 1 ng/mL IGF-I = 0.130 nM IGF-I and 1 ng/mL IGFBP3 = 0.036 nM IGFBP-3.
*p < 0.03;**p < 0.005; two-tailed t-test.

ISSN: 1471-2407