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Table 4 Effect of voluntary exercise on body weights, regional fat weights, and colon tumor formation in AOM/DSS-treated mice on high-fat dieta

From: Voluntary exercise inhibits intestinal tumorigenesis in Apc Min/+mice and azoxymethane/dextran sulfate sodium-treated mice

Groups (N)

Final body weight per mouse (g)

Omental fat weight/final body weight per mouse (mg/g)

Retroperitoneal fat weight/body weight per mouse (mg/g)

Tumor incidence

No. of tumor per mouse

No. of tumor per tumor-bearing/mouse

Average tumor dimensionb per tumor (mm)

Control (22)

49.9 ± 1.7

32.7 ± 3.6

10.6 ± 1.2

10/22 (46%)

1.9 ± 0.6

4.1 ± 1.0

2.7 ± 0.03

Exercise (17)

43.0 ± 1.2*

12.4 ± 2.6**

4.2 ± 1.0**

9/17 (53%)

1.1 ± 0.3

2.0 ± 0.2*

2.9 ± 0.07

  1. aResults of Experiment 3. The mice were maintained on a high-fat diet and housed in regular cages or cages equipped with a running wheel for 16 weeks. Values are mean ± SE of the number of samples (N) analyzed.
  2. bAverage of length, width, and height of each tumor. There was no difference in the average volume of tumors (mm3) calculated using the formula V = 4/3πr 3 (r :the average dimention/2) between the two groups.
  3. **p < 0.05 by two-tailed t-test. *p = 0.06 by two-tailed t-test and p = 0.03 by one-tailed t-test. Values with no superscript did not differ from the values of the control group statistically (p > 0.05)