Figure 1

Visual depiction of the similarity between gene expression and genomic data. A. Summary of gene expression data for all 79 samples. The distribution of 2853 progression genes over the chromosome arms is shown. The x-axis shows all chromosome arms, the y-axis shows the percentage of genes for a certain chromosome arm that is differentially expressed. White bars represent downregulated genes, black bars represent upregulated genes. B. Heat map of all gene expression data for the 66 samples with 18q genomic data available. Every column represents a single sample. Samples on the left side show loss of 18q, while samples on the right side show retention of chromosome 18q, both measured by SNP arrays. The y-axis shows all 18q genes from the centromere to telomere. Red lines indicate genes with a higher expression, green lines a lower expression. C. Chromosomal plot of sample 203 (carcinoma with lymph node metastasis) based on SNP array data (red) and gene expression array data (green).