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Table 3 Associations between leptin, ObR, leptin/ObR and different clinicopathological parameters

From: Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivoanalysis

    Leptin ObR
   N Positive (%) p-value Positive (%) p-value
Diameter (mm)     0.061   0.137
  ≤ 10 mm 9 55.6   66.7  
  > 10 mm 42 85.7   88.1  
N     > 0.5   0.242
  N0 19 84.2   94.7  
  N+ (N > 0) 33 78.8   81.8  
LVI     > 0.5   0.473
  Negative 24 79.2   87.5  
  Positive 27 77.8   77.8  
Menopausal status     > 0.5   > 0.5
  Postmenopausal 15 80.0   86.7  
  Premenopausal 39 82.1   84.6  
Histotype     > 0.5   0.432
  Other 3 66.7   66.7  
  Ductal (invasive) 45 80.0   84.4  
  Inflammatory 4 100.0   100.0  
  Intraductal 3 66.7   66.7  
  Lobular (invasive) 4 75.0   75.0  
G     0.495   0.366
  G1 7 85.7   100.0  
  G2 18 88.9   88.9  
  G3 26 73.1   76.9  
Ki-67     > 0.5   > 0.5
  0–15% 33 75.8   81.8  
  16–25% 9 88.9   88.9  
  26–100% 14 85.7   85.7  
ER/PgR     > 0.5   > 0.5
  ER-/PgR- 12 75.0   83.3  
  ER-/PgR+ 1 100.0   100.0  
  ER+/PgR- 6 83.3   83.3  
  ER+/PgR+ 37 81.1   83.8  
T     0.019   0.400
  pT1 20 70.0   80.0  
  pT2 23 91.3   91.3  
  pT3 2 0.0   50.0  
  pT4 8 100.0   87.5  
  pTx 1 100.0   100.0  
  TIS 3 66.7   66.7  
HER2     0.342   0.306
  Negative 28 85.7   89.3  
  Positive 31 74.2   77.4  
  1. For each level of each clinicopathological variable, the total number (N) of patients is given together with the percentage of subjects positive for leptin or ObR expression. Abbreviations as in Tab. 2.