TY - JOUR AU - Fiorio, Elena AU - Mercanti, Anna AU - Terrasi, Marianna AU - Micciolo, Rocco AU - Remo, Andrea AU - Auriemma, Alessandra AU - Molino, Annamaria AU - Parolin, Veronica AU - Di Stefano, Bruno AU - Bonetti, Franco AU - Giordano, Antonio AU - Cetto, Gian Luigi AU - Surmacz, Eva PY - 2008 DA - 2008/10/22 TI - Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivoanalysis JO - BMC Cancer SP - 305 VL - 8 IS - 1 AB - Obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive tumors and resistance to certain anti-breast cancer treatments. Some of these effects might be mediated by obesity hormone leptin, acting independently or modulating other signaling pathways. Here we focused on the link between leptin and HER2. We tested if HER2 and the leptin receptor (ObR) can be coexpressed in breast cancer cell models, whether these two receptors can physically interact, and whether leptin can transactivate HER2. Next, we studied if leptin/ObR can coexist with HER2 in breast cancer tissues, and if presence of these two systems correlates with specific clinicopathological features. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-8-305 DO - 10.1186/1471-2407-8-305 ID - Fiorio2008 ER -