TY - JOUR AU - Jemal, A. AU - Siegel, R. AU - Ward, E. AU - Murray, T. AU - Xu, J. AU - Thun, M. J. PY - 2007 DA - 2007// TI - Cancer statistics, 2007 JO - CA Cancer J Clin VL - 57 UR - https://doi.org/10.3322/canjclin.57.1.43 DO - 10.3322/canjclin.57.1.43 ID - Jemal2007 ER - TY - JOUR AU - Chen, W. Y. AU - Colditz, G. A. PY - 2007 DA - 2007// TI - Risk factors and hormone-receptor status: epidemiology, risk-prediction models and treatment implications for breast cancer JO - Nat Clin Pract Oncol VL - 4 UR - https://doi.org/10.1038/ncponc0851 DO - 10.1038/ncponc0851 ID - Chen2007 ER - TY - JOUR AU - Evans, J. P. AU - Skrzynia, C. AU - Susswein, L. AU - Harlan, M. PY - 2005 DA - 2005// TI - Genetics and the young woman with breast cancer JO - Breast Dis VL - 23 UR - https://doi.org/10.3233/BD-2006-23104 DO - 10.3233/BD-2006-23104 ID - Evans2005 ER - TY - JOUR AU - O'Sullivan, L. A. AU - Liongue, C. AU - Lewis, R. S. AU - Stephenson, S. E. AU - Ward, A. C. PY - 2007 DA - 2007// TI - Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease JO - Mol Immunol VL - 44 UR - https://doi.org/10.1016/j.molimm.2006.11.025 DO - 10.1016/j.molimm.2006.11.025 ID - O'Sullivan2007 ER - TY - JOUR AU - Yu, H. AU - Jove, R. PY - 2004 DA - 2004// TI - The STATs of cancer – new molecular targets come of age JO - Nat Rev Cancer VL - 4 UR - https://doi.org/10.1038/nrc1275 DO - 10.1038/nrc1275 ID - Yu2004 ER - TY - JOUR AU - Haura, E. B. AU - Turkson, J. AU - Jove, R. PY - 2005 DA - 2005// TI - Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer JO - Nat Clin Pract Oncol VL - 2 UR - https://doi.org/10.1038/ncponc0195 DO - 10.1038/ncponc0195 ID - Haura2005 ER - TY - JOUR AU - Bowman, T. AU - Garcia, R. AU - Turkson, J. AU - Jove, R. PY - 2000 DA - 2000// TI - STATs in oncogenesis JO - Oncogene VL - 19 UR - https://doi.org/10.1038/sj.onc.1203527 DO - 10.1038/sj.onc.1203527 ID - Bowman2000 ER - TY - JOUR AU - Ihle, J. N. PY - 2001 DA - 2001// TI - The Stat family in cytokine signaling JO - Curr Opin Cell Biol VL - 13 UR - https://doi.org/10.1016/S0955-0674(00)00199-X DO - 10.1016/S0955-0674(00)00199-X ID - Ihle2001 ER - TY - JOUR AU - Darnell, J. E. PY - 1997 DA - 1997// TI - STATs and gene regulation JO - Science VL - 277 UR - https://doi.org/10.1126/science.277.5332.1630 DO - 10.1126/science.277.5332.1630 ID - Darnell1997 ER - TY - JOUR AU - Ihle, J. N. AU - Witthuhn, B. A. AU - Quelle, F. W. AU - Yamamoto, K. AU - Silvennoinen, O. PY - 1995 DA - 1995// TI - Signaling through the hematopoietic cytokine receptors JO - Annu Rev Immunol VL - 13 UR - https://doi.org/10.1146/annurev.iy.13.040195.002101 DO - 10.1146/annurev.iy.13.040195.002101 ID - Ihle1995 ER - TY - JOUR AU - Copeland, N. G. AU - Gilbert, D. J. AU - Schindler, C. AU - Zhong, Z. AU - Wen, Z. AU - Darnell, J. E. AU - Mui, A. L. AU - Miyajima, A. AU - Quelle, F. W. AU - Ihle, J. N. PY - 1995 DA - 1995// TI - Distribution of the mammalian Stat gene family in mouse chromosomes JO - Genomics VL - 29 UR - https://doi.org/10.1006/geno.1995.1235 DO - 10.1006/geno.1995.1235 ID - Copeland1995 ER - TY - JOUR AU - Bromberg, J. F. AU - Wrzeszczynska, M. H. AU - Devgan, G. AU - Zhao, Y. AU - Pestell, R. G. AU - Albanese, C. AU - Darnell, J. E. PY - 1999 DA - 1999// TI - Stat3 as an oncogene JO - Cell VL - 98 UR - https://doi.org/10.1016/S0092-8674(00)81959-5 DO - 10.1016/S0092-8674(00)81959-5 ID - Bromberg1999 ER - TY - JOUR AU - Hanahan, D. AU - Weinberg, R. A. PY - 2000 DA - 2000// TI - The hallmarks of cancer JO - Cell VL - 100 UR - https://doi.org/10.1016/S0092-8674(00)81683-9 DO - 10.1016/S0092-8674(00)81683-9 ID - Hanahan2000 ER - TY - JOUR AU - Yeh, H. H. AU - Lai, W. W. AU - Chen, H. H. AU - Liu, H. S. AU - Su, W. C. PY - 2006 DA - 2006// TI - Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion JO - Oncogene VL - 25 UR - https://doi.org/10.1038/sj.onc.1209464 DO - 10.1038/sj.onc.1209464 ID - Yeh2006 ER - TY - JOUR AU - Buettner, R. AU - Mora, L. B. AU - Jove, R. PY - 2002 DA - 2002// TI - Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention JO - Clin Cancer Res VL - 8 ID - Buettner2002 ER - TY - JOUR AU - Garcia, R. AU - Yu, C. L. AU - Hudnall, A. AU - Catlett, R. AU - Nelson, K. L. AU - Smithgall, T. AU - Fujita, D. J. AU - Ethier, S. P. AU - Jove, R. PY - 1997 DA - 1997// TI - Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells JO - Cell Growth Differ VL - 8 ID - Garcia1997 ER - TY - JOUR AU - Watson, C. J. AU - Miller, W. R. PY - 1995 DA - 1995// TI - Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts JO - Br J Cancer VL - 71 UR - https://doi.org/10.1038/bjc.1995.162 DO - 10.1038/bjc.1995.162 ID - Watson1995 ER - TY - JOUR AU - Bowman, T. AU - Broome, M. A. AU - Sinibaldi, D. AU - Wharton, W. AU - Pledger, W. J. AU - Sedivy, J. M. AU - Irby, R. AU - Yeatman, T. AU - Courtneidge, S. A. AU - Jove, R. PY - 2001 DA - 2001// TI - Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis JO - Proc Natl Acad Sci USA VL - 98 UR - https://doi.org/10.1073/pnas.131568898 DO - 10.1073/pnas.131568898 ID - Bowman2001 ER - TY - JOUR AU - Clevenger, C. V. PY - 2004 DA - 2004// TI - Roles and regulation of stat family transcription factors in human breast cancer JO - Am J Pathol VL - 165 UR - https://doi.org/10.1016/S0002-9440(10)63403-7 DO - 10.1016/S0002-9440(10)63403-7 ID - Clevenger2004 ER - TY - JOUR AU - Sung, S. Y. AU - Hsieh, C. L. AU - Wu, D. AU - Chung, L. W. AU - Johnstone, P. A. PY - 2007 DA - 2007// TI - Tumor microenvironment promotes cancer progression, metastasis, and therapeutic resistance JO - Curr Probl Cancer VL - 31 UR - https://doi.org/10.1016/j.currproblcancer.2006.12.002 DO - 10.1016/j.currproblcancer.2006.12.002 ID - Sung2007 ER - TY - JOUR AU - Ronnov-Jessen, L. AU - Petersen, O. W. AU - Bissell, M. J. PY - 1996 DA - 1996// TI - Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction JO - Physiol Rev VL - 76 ID - Ronnov-Jessen1996 ER - TY - JOUR AU - Tlsty, T. D. AU - Hein, P. W. PY - 2001 DA - 2001// TI - Know thy neighbor: stromal cells can contribute oncogenic signals JO - Curr Opin Genet Dev VL - 11 UR - https://doi.org/10.1016/S0959-437X(00)00156-8 DO - 10.1016/S0959-437X(00)00156-8 ID - Tlsty2001 ER - TY - JOUR AU - Bhowmick, N. A. AU - Moses, H. L. PY - 2005 DA - 2005// TI - Tumor-stroma interactions JO - Curr Opin Genet Dev VL - 15 UR - https://doi.org/10.1016/j.gde.2004.12.003 DO - 10.1016/j.gde.2004.12.003 ID - Bhowmick2005 ER - TY - JOUR AU - Bhowmick, N. A. AU - Neilson, E. G. AU - Moses, H. L. PY - 2004 DA - 2004// TI - Stromal fibroblasts in cancer initiation and progression JO - Nature VL - 432 UR - https://doi.org/10.1038/nature03096 DO - 10.1038/nature03096 ID - Bhowmick2004 ER - TY - JOUR AU - van Roozendaal, C. E. AU - van Ooijen, B. AU - Klijn, J. G. AU - Claassen, C. AU - Eggermont, A. M. AU - Henzen-Logmans, S. C. AU - Foekens, J. A. PY - 1992 DA - 1992// TI - Stromal influences on breast cancer cell growth JO - Br J Cancer VL - 65 UR - https://doi.org/10.1038/bjc.1992.14 DO - 10.1038/bjc.1992.14 ID - van Roozendaal1992 ER - TY - JOUR AU - Kalluri, R. AU - Zeisberg, M. PY - 2006 DA - 2006// TI - Fibroblasts in cancer JO - Nat Rev Cancer VL - 6 UR - https://doi.org/10.1038/nrc1877 DO - 10.1038/nrc1877 ID - Kalluri2006 ER - TY - JOUR AU - Yu, H. AU - Kortylewski, M. AU - Pardoll, D. PY - 2007 DA - 2007// TI - Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment JO - Nat Rev Immunol VL - 7 UR - https://doi.org/10.1038/nri1995 DO - 10.1038/nri1995 ID - Yu2007 ER - TY - JOUR AU - Lim, C. P. AU - Cao, X. PY - 2006 DA - 2006// TI - Structure, function, and regulation of STAT proteins JO - Mol Biosyst VL - 2 UR - https://doi.org/10.1039/b606246f DO - 10.1039/b606246f ID - Lim2006 ER - TY - JOUR AU - Wen, Z. AU - Darnell, J. E. PY - 1997 DA - 1997// TI - Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3 JO - Nucleic Acids Res VL - 25 UR - https://doi.org/10.1093/nar/25.11.2062 DO - 10.1093/nar/25.11.2062 ID - Wen1997 ER - TY - JOUR AU - Garcia, R. AU - Bowman, T. L. AU - Niu, G. AU - Yu, H. AU - Minton, S. AU - Muro-Cacho, C. A. AU - Cox, C. E. AU - Falcone, R. AU - Fairclough, R. AU - Parsons, S. PY - 2001 DA - 2001// TI - Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells JO - Oncogene VL - 20 UR - https://doi.org/10.1038/sj.onc.1204349 DO - 10.1038/sj.onc.1204349 ID - Garcia2001 ER - TY - JOUR AU - Blaskovich, M. A. AU - Sun, J. AU - Cantor, A. AU - Turkson, J. AU - Jove, R. AU - Sebti, S. M. PY - 2003 DA - 2003// TI - Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice JO - Cancer Res VL - 63 ID - Blaskovich2003 ER - TY - JOUR AU - Berishaj, M. AU - Gao, S. P. AU - Ahmed, S. AU - Leslie, K. AU - Al-Ahmadie, H. AU - Gerald, W. L. AU - Bornmann, W. AU - Bromberg, J. F. PY - 2007 DA - 2007// TI - Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer JO - Breast Cancer Res VL - 9 UR - https://doi.org/10.1186/bcr1680 DO - 10.1186/bcr1680 ID - Berishaj2007 ER - TY - JOUR AU - Chen, C. L. AU - Hsieh, F. C. AU - Lieblein, J. C. AU - Brown, J. AU - Chan, C. AU - Wallace, J. A. AU - Cheng, G. AU - Hall, B. M. AU - Lin, J. PY - 2007 DA - 2007// TI - Stat3 activation in human endometrial and cervical cancers JO - Br J Cancer VL - 96 UR - https://doi.org/10.1038/sj.bjc.6603597 DO - 10.1038/sj.bjc.6603597 ID - Chen2007 ER - TY - JOUR AU - Knupfer, H. AU - Preiss, R. PY - 2007 DA - 2007// TI - Significance of interleukin-6 (IL-6) in breast cancer (review) JO - Breast Cancer Res Treat VL - 102 UR - https://doi.org/10.1007/s10549-006-9328-3 DO - 10.1007/s10549-006-9328-3 ID - Knupfer2007 ER - TY - JOUR AU - Zhong, Z. AU - Wen, Z. AU - Darnell, J. E. PY - 1994 DA - 1994// TI - Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6 JO - Science VL - 264 UR - https://doi.org/10.1126/science.8140422 DO - 10.1126/science.8140422 ID - Zhong1994 ER - TY - JOUR AU - Sasser, A. K. AU - Sullivan, N. J. AU - Studebaker, A. W. AU - Hendey, L. F. AU - Axel, A. E. AU - Hall, B. M. PY - 2007 DA - 2007// TI - Interleukin-6 is a potent growth factor for ER-alpha-positive human breast cancer JO - Faseb J VL - 21 UR - https://doi.org/10.1096/fj.07-8832com DO - 10.1096/fj.07-8832com ID - Sasser2007 ER - TY - JOUR AU - Chang, J. C. AU - Wooten, E. C. AU - Tsimelzon, A. AU - Hilsenbeck, S. G. AU - Gutierrez, M. C. AU - Tham, Y. L. AU - Kalidas, M. AU - Elledge, R. AU - Mohsin, S. AU - Osborne, C. K. PY - 2005 DA - 2005// TI - Patterns of resistance and incomplete response to docetaxel by gene expression profiling in breast cancer patients JO - J Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.03.156 DO - 10.1200/JCO.2005.03.156 ID - Chang2005 ER - TY - JOUR AU - Real, P. J. AU - Sierra, A. AU - De Juan, A. AU - Segovia, J. C. AU - Lopez-Vega, J. M. AU - Fernandez-Luna, J. L. PY - 2002 DA - 2002// TI - Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells JO - Oncogene VL - 21 UR - https://doi.org/10.1038/sj.onc.1206004 DO - 10.1038/sj.onc.1206004 ID - Real2002 ER - TY - JOUR AU - Hsieh, F. C. AU - Cheng, G. AU - Lin, J. PY - 2005 DA - 2005// TI - Evaluation of potential Stat3-regulated genes in human breast cancer JO - Biochem Biophys Res Commun VL - 335 UR - https://doi.org/10.1016/j.bbrc.2005.07.075 DO - 10.1016/j.bbrc.2005.07.075 ID - Hsieh2005 ER - TY - JOUR AU - Gu, B. AU - Espana, L. AU - Mendez, O. AU - Torregrosa, A. AU - Sierra, A. PY - 2004 DA - 2004// TI - Organ-selective chemoresistance in metastasis from human breast cancer cells: inhibition of apoptosis, genetic variability and microenvironment at the metastatic focus JO - Carcinogenesis VL - 25 UR - https://doi.org/10.1093/carcin/bgh272 DO - 10.1093/carcin/bgh272 ID - Gu2004 ER - TY - JOUR AU - Duan, Z. AU - Foster, R. AU - Bell, D. A. AU - Mahoney, J. AU - Wolak, K. AU - Vaidya, A. AU - Hampel, C. AU - Lee, H. AU - Seiden, M. V. PY - 2006 DA - 2006// TI - Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer JO - Clin Cancer Res VL - 12 UR - https://doi.org/10.1158/1078-0432.CCR-06-0861 DO - 10.1158/1078-0432.CCR-06-0861 ID - Duan2006 ER - TY - JOUR AU - Rincon, M. AU - Broadwater, G. AU - Harris, L. AU - Crocker, A. AU - Weaver, D. AU - Dressler, L. AU - Berry, D. AU - Sutton, L. AU - Michaelson, R. AU - Messino, M. PY - 2006 DA - 2006// TI - Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: results of cancer and leukemia group B trial 159806 JO - Breast Cancer Res Treat VL - 100 UR - https://doi.org/10.1007/s10549-006-9251-7 DO - 10.1007/s10549-006-9251-7 ID - Rincon2006 ER - TY - JOUR AU - Sehgal, P. B. AU - Tamm, I. PY - 1990 DA - 1990// TI - Interleukin-6 enhances motility of breast cancer cells JO - Cancer Invest VL - 8 UR - https://doi.org/10.3109/07357909009018940 DO - 10.3109/07357909009018940 ID - Sehgal1990 ER - TY - JOUR AU - Conze, D. AU - Weiss, L. AU - Regen, P. S. AU - Bhushan, A. AU - Weaver, D. AU - Johnson, P. AU - Rincon, M. PY - 2001 DA - 2001// TI - Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells JO - Cancer Res VL - 61 ID - Conze2001 ER - TY - JOUR AU - Yao, C. AU - Lin, Y. AU - Chua, M. S. AU - Ye, C. S. AU - Bi, J. AU - Li, W. AU - Zhu, Y. F. AU - Wang, S. M. PY - 2007 DA - 2007// TI - Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells JO - Int J Cancer VL - 121 UR - https://doi.org/10.1002/ijc.22930 DO - 10.1002/ijc.22930 ID - Yao2007 ER - TY - JOUR AU - Bendre, M. S. AU - Gaddy-Kurten, D. AU - Mon-Foote, T. AU - Akel, N. S. AU - Skinner, R. A. AU - Nicholas, R. W. AU - Suva, L. J. PY - 2002 DA - 2002// TI - Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo JO - Cancer Res VL - 62 ID - Bendre2002 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/8/302/prepub UR - http://www.biomedcentral.com/1471-2407/8/302/prepub ID - ref47 ER -