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Table 3 EGFR and HER2-neu status of ovarian tumours

From: Genomic activation of the EGFR and HER2-neu genes in a significant proportion of invasive epithelial ovarian cancers

   EGFR (ErbB-1) HER2-neu (ErbB-2)  
Histopathological subtype (N = 52)   IHC (N = 31) FISH (N = 27) TKD Mutation (N = 68) IHC (N = 31) FISH (N = 6) amplification TKD Mutation (N = 68)
   0 1+ 2/3+ < 2 P   0 1+ 2/3+   
Adenocarcinoma:             
Serous 27 7 4 8 17 3 34 11 4 4 2 34
Mucinous 4 1 1 1 3 0 6 3 0 0 0 6
Endometroid 21 3 2 4 7 1 28 5 2 2 1 28
  1. Fifty-two ovarian tumours were analyzed by immunohistochemistry, FISH and mutation status for EGFR (ErBb-1) and HER2-neu (ErBb-2). The IHC scores and definition of gene amplification are specified in the methods section. For EGFR no amplification was found. For HER2-neu the gene copy number was only examined in the 6 cancers with 2/3+ IHC.
  2. N = number of cases, P = "high polysomy", 0 = absent, TKD = tyrosine kinase domain.