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Table 3 EGFR and HER2-neu status of ovarian tumours

From: Genomic activation of the EGFR and HER2-neu genes in a significant proportion of invasive epithelial ovarian cancers

  

EGFR (ErbB-1)

HER2-neu (ErbB-2)

 

Histopathological subtype (N = 52)

 

IHC (N = 31)

FISH (N = 27)

TKD Mutation (N = 68)

IHC (N = 31)

FISH (N = 6) amplification

TKD Mutation (N = 68)

  

0

1+

2/3+

< 2

P

 

0

1+

2/3+

  

Adenocarcinoma:

            

Serous

27

7

4

8

17

3

34

11

4

4

2

34

Mucinous

4

1

1

1

3

0

6

3

0

0

0

6

Endometroid

21

3

2

4

7

1

28

5

2

2

1

28

  1. Fifty-two ovarian tumours were analyzed by immunohistochemistry, FISH and mutation status for EGFR (ErBb-1) and HER2-neu (ErBb-2). The IHC scores and definition of gene amplification are specified in the methods section. For EGFR no amplification was found. For HER2-neu the gene copy number was only examined in the 6 cancers with 2/3+ IHC.
  2. N = number of cases, P = "high polysomy", 0 = absent, TKD = tyrosine kinase domain.
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BMC Cancer

ISSN: 1471-2407

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