Prognostic parameters for recurrence of papillary thyroid microcarcinoma

BMC Cancer

Table 4 Subgroup analyses of association of clinical recurrence in 251 patients with PTMC according to surgical extent after excluding patients without pathologic N staging information

Baseline characteristics	Patients with total or near-total thyroidectomy (n = 150)			Patients with hemi- or subtotal thyroidectomy (n = 101)			Overall (n = 251)
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Age at operation
≤ 45 yrs	1.75	0.41–7.39	0.45	INF	NC	0.99	2.38	0.63–8.98	0.20
> 45 yrs	1.00	-	-	1.00	-	-	1.00	-	-
Gender
Men	5.35	1.28–22.4	0.02	24.2	2.17–270	0.01	7.59	2.31–25.0	0.001
Women	1.00	-	-	1.00	-	-	1.00	-	-
Tumor size
Per 1 mm increase	1.17	0.79–1.72	0.44	1.36	.0.67–2.76	0.4	1.23	0.86–1.74	0.26
Multifocality
Solitary tumor	1.58	0.38–6.62	0.53	0.18	0.02–1.93	0.16	0.9	0.26–3.08	0.86
Multifocal tumor	1.00	-	-	1.00	-	-	1.00	-	-
Extrathyroid extension
Absent	0.53	0.13–2.23	0.39	INF	NC	1	0.77	0.23–2.52	0.66
Present	1.00	-	-	1.00	-	-	1.00	-	-
Lymph node metastasis			0.04			1			0.03
pN0	0	NC	1	0	NC	0.99	0	NC	0.99
pN1a^a	1.00	-	-	1.00	-	-	1.00	-	-
pN1b^b	8.25	1.66–40.9	0.01	N/A			5.14	1.56–17.0	0.007
Bilaterality
Unilateral tumor	0.74	0.18–3.11	0.69	N/A			0.65	0.17–2.47	0.53
Bilateral tumor	1.00	-	-				1.00	-	-
Remnant ablation
Not done	0	NC	1	N/A			N/A
Done	1.00	-	-

^a Metastases to level VI lymph nodes (pretracheal, paratracheal, and prelaryngeal/Delphian lymph nodes), classified as N1a in the 2002 TNM staging.
^b Metastases to unilateral, bilateral, or contralateral cervical superior mediastinal lymph nodes, classified as N1b in the 2002 TNM staging.
Percent recurrence rates were given in parentheses; CI, confidence interval; N/A, not applicable; INF, infinite; NC, cannot calculate; HR, hazard ratio.

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