Prognostic parameters for recurrence of papillary thyroid microcarcinoma

Kim, Tae Yong; Hong, Suck Joon; Kim, Jung Min; Gu Kim, Won; Gong, Gyungyub; Ryu, Jin Sook; Kim, Won Bae; Yun, Sung-Cheol; Shong, Young Kee

doi:10.1186/1471-2407-8-296

BMC Cancer

Table 2 Clinical characteristics of patients with clinical recurrence

From: Prognostic parameters for recurrence of papillary thyroid microcarcinoma

Patient No.	1	2	3	4	5	6	7
Age/Sex	46/M	32/M	43/M	38/F	60/F	44/F	63/F
Initial Surgical extent	TT, MRND	TT, CND	TT, MRND	TT, MRND	TT, MRND	TT, CND	TT, MRND
I-131 Remnant ablation	done	Done	done	done	Done	done	done
Just before recurrence
sTg (ng/mL)	58.6	34.4	17.3	13.8	33	21.5	20.7
TgAb	negative	Negative	negative	positive	negative	negative	negative
Disease free survival (months)	9	11	13	24	31	35	43
Type of recurrence (Level of recurrent node confirmed by reoperation)^c	regional (i/l II, III, IV)	regional (i/l III, SCN)	regional (i/l II, III, IV)	regional (i/l II, III, IV, SCN, VII)	regional (thyroid bed)	regional (i/l IV; c/l III, IV)	regional (i/l II, III, IV)
Additional treatment	surgery, ¹³¹I	surgery, ¹³¹I	surgery, ¹³¹I, EBRT	surgery	surgery, ¹³¹I, EBRT	surgery, ¹³¹I	surgery, ¹³¹I
Follow-up
sTg (ng/mL)	UD	12.6	1.1	8.7	944^a	12.4	40.0^b
TgAb	negative	negative	negative	positive	negative	negative	negative
Patient No.	8	9	10	11	12	13	14
Age/Sex	42/F	50/F	40/F	43/F	32/F	40 M	33/M
Initial Surgical extent	TT, MRND	STT	LOB	LOB	LOB, CND	LOB, CND	LOB, CND
I-131 Remnant ablation	done	not done	not done	not done	not done	not done	not done
Just before recurrence
sTg (ng/mL)	1.1	N/A	N/A	N/A	N/A	N/A	N/A
TgAb	neg	N/A	N/A	N/A	N/A	N/A	N/A
Disease free survival (months)	99	8	10	15	44	53	63
Type of recurrence (Level of recurrent node confirmed by reoperation)^c	regional (i/l II, III)	regional (i/l III, IV)	local (c/l lobe)	local (c/l lobe)	local (c/l lobe)	local (c/l lobe)	local (c/l lobe)
Additional treatment	surgery, ¹³¹I	surgery, ¹³¹I	follow-up loss	surgery, ¹³¹I	surgery, ¹³¹I	surgery, ¹³¹I	surgery, ¹³¹I
Follow-up
sTg (ng/mL)	UD	UD		UD	UD	UD	UD
TgAb	negative	positive		negative	negative	negative	negative

^a Chest CT suggested multiple lung metastases. This patient underwent additional surgery and radioiodine treatment, but no iodide uptake was noted during a post-treatment whole body scan. This patient, however, showed progressive, multiple, unresectable, cervical, mediastinal, and lung metastases, and EBRT was performed to control locally advanced disease.
^b Chest CT and FDG-PET suggested multiple lung metastases. This patient underwent additional surgery and radioiodine treatment, but no iodide uptake was noted during a post-treatment whole body scan. This was followed by thyroxine suppression, with no definitive evidence of disease progression observed on serial chest CT scans.
sTg, stimulated thyroglobulin; TT, total thyroidectomy; STT, subtotal thyroidectomy; LOB, lobectomy; CND, central neck node dissection; MRND, modified radical neck dissection; UD, undetectable; N/A, not applicable; i/l, ipsilateral; c/l, contralateral; EBRT, external beam radiation treatment.

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ISSN: 1471-2407

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