Figure 1

Relative mRNA expression of selected genes in specimens from patients with ovarian carcinomas. A. – samples divided according to mutational status of the mtDNA D-loop (W – wild type, n = 19; M – mutated, n = 25). B. – samples divided according to response to chemotherapy (S – sensitive, n = 32; R – resistant, n = 30). Data are presented as mRNA expression levels for selected genes normalized to the geometric mean of the RNA concentrations of three control genes, glyceraldehyde-3-phosphate dehydrogenase, ubiquitin C, and β-actin. The boxes show the upper and the lower quartiles; the median values are shown as a horizontal line in each box; the whiskers represent minimum and maximum of the data values. Data were analyzed with the Mann-Whitney U test.