Figure 1

Array CGH of 8p in 38 cancer cell lines. The ideogram shows the short arm of chromosome 8 with the position of the chromosome bands indicated on the left and regions of recurrent change represented by coloured boxes on the right of the ideogram. Previously identified positions of recurrent rearrangement (8p11-12) are indicated by a dashed outline. The novel regions identified by this study are indicated by a solid outline. For these summary boxes red indicates a common region of loss in 8p23.3, green a common region of gain/amplification in 8p21.3 and white indicates a region with various rearrangements including gain, loss and breakpoints in 8p22. Array CGH results are displayed as a heat map using CGHAnalyzer (http://acgh.afcri.upenn.edu, [64]). The first twenty-four lines show a typical pattern of 8p12 rearrangement with breakpoints, distal loss and occasionally proximal amplification. The next four lines have atypical patterns of 8p rearrangement. The final ten lines show no copy number changes within 8p but the last five have lost the whole of 8p with respect to 8q. Red, loss relative to the ploidy of the cell line; Black, no change; Green, gain; Yellow, high level amplification; Grey, no copy number data; * indicates a pancreatic line.