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Table 4 Apoptosis-related factors in DCIS and DCIS-Mi

From: Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion

  DCIS DCIS-Mi P-value
Apoptotic Index (N/1000) 1.7 ± 0.4 2.9 ± 0.6 0.082
Bcl-2    
   negative 21 (41.2%) 6 (21.4%) 0.071
   Positive 30 (58.8%) 22 (78.6%)  
Bax    
   negative 15 (28.8%) 1 (3.6%) 0.0028
   Positive 37 (71.2%) 27 (96.4%)  
Survivin    
   negative 23 (44.2%) 4 (14.3%) 0.0048
   positive 29 (55.8%) 24 (85.7%)  
p53    
   positive 39 (76.5%) 23 (82.1%) 0.55
   Negative 12 (23.5%) 5 (17.9%)  
p21    
   positive 36 (69.2%) 15 (53.6%) 0.17
   negative 16 (30.8%) 13 (46.4%)  
cyclinD1    
   positive 36 (70.6%) 18 (64.3%) 0.57
   Negative 15 (29.4%) 10 (35.7%)  
Rb    
   positive 35 (68.6%) 23 (82.1%) 0.18
   negative 16 (31.4%) 5 (17.9%)  
  1. DCIS = ductal carcinoma in situ; DCIS-Mi = ductal carcinoma in situ with microinvasion.