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Table 1 Histological characteristics of intraductal component in ductal carcinoma in situ (DCIS) and in ductal carcinoma in situ with microinvasion (DCIS-Mi)

From: Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion

  DCIS DCIS-Mi  
Number of patients 52 28  
Median follow-up period, months (range) 62 (3–140) 54 (14–182)  
Median age, years (range) 56 (36–86) 50 (32–71)  
Architectural classification    
   comedo 8 (15.4%) 10(35.7%) P = 0.073
   Papillary 21 (40.4%) 10 (35.7%) (comedo vs others)
   cribriform 15 (28.8%) 4 (14.3%)  
   solid 4 (7.7%) 4 (14.3%)  
   low papillary 4 (7.7%) 0 (0)  
Nuclear Grade    
   Grade 1 21 (40.4%) 7 (25) P = 0.16
   Grade 2 29 (55.8%) 18 (64.3) (1 vs. 2,3)
   Grade 3 2 (3.9%) 3 (10.7)  
Necrosis    
   absent 25 (48.1%) 4 (14.3%) P = 0.0017
   Present 27 (51.9%) 24 (85.7%)  
Van Nuys Classification*    
   Grade 1 25 (48.1%) 4 (14.3%) P = 0.0017
   Grade 2 25 (48.1%) 21 (75%) (1 vs. 2,3)
   Grade 3 2 (3.9%) 3 (10.7%)  
  1. * Van Nuys Classification: Grade 1 = non-high nuclear grade without necrosis; Grade 2 = non-high nuclear grade with necrosis; Grade 3 = high-nuclear grade.