From: Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion
 | DCIS | DCIS-Mi |  |
---|---|---|---|
Number of patients | 52 | 28 | Â |
Median follow-up period, months (range) | 62 (3–140) | 54 (14–182) |  |
Median age, years (range) | 56 (36–86) | 50 (32–71) |  |
Architectural classification | Â | Â | Â |
   comedo | 8 (15.4%) | 10(35.7%) | P = 0.073 |
   Papillary | 21 (40.4%) | 10 (35.7%) | (comedo vs others) |
   cribriform | 15 (28.8%) | 4 (14.3%) |  |
   solid | 4 (7.7%) | 4 (14.3%) |  |
   low papillary | 4 (7.7%) | 0 (0) |  |
Nuclear Grade | Â | Â | Â |
   Grade 1 | 21 (40.4%) | 7 (25) | P = 0.16 |
   Grade 2 | 29 (55.8%) | 18 (64.3) | (1 vs. 2,3) |
   Grade 3 | 2 (3.9%) | 3 (10.7) |  |
Necrosis | Â | Â | Â |
   absent | 25 (48.1%) | 4 (14.3%) | P = 0.0017 |
   Present | 27 (51.9%) | 24 (85.7%) |  |
Van Nuys Classification* | Â | Â | Â |
   Grade 1 | 25 (48.1%) | 4 (14.3%) | P = 0.0017 |
   Grade 2 | 25 (48.1%) | 21 (75%) | (1 vs. 2,3) |
   Grade 3 | 2 (3.9%) | 3 (10.7%) |  |