Interactions between HSP27 and Her2, and reduced Her2 levels after HSP27 suppression. (a) Western-blot analysis of immunoprecipitates of anti-Her2 and anti-HSP2 antibodies. (b) Reduced Her2 levels associated with HSP27 suppression. (c) Reduced levels of Her2 in control and HSP27-suppressed cells in the presence of Herceptin. Data (b, c) are means ± standard deviations of three independent experiments.