Table 4 PCA3 mRNA detection in the peripheral blood of PCa and BPH patients across genotypic SSCP conformations and their haplotypes.
From: The -786T>C promoter polymorphism of the NOS3gene is associated with prostate cancer progression
Positive PCA3mRNA (N = 40) | Negative PCA3mRNA (N = 109) | ||||||
|---|---|---|---|---|---|---|---|
SSCP | Genotypes | PCa N (%) | BPH N (%) | Total | PCa N (%) | BPH N (%) | Total |
TN | [-786T>C] + [=] [-690C>T] + [=] [-649G>A] + [=] | 0 | 0 | 0/0 | 1 (0.9) | 0 | 1/109 (0.9) |
CC | [-786T>C] + [-786T>C] [-714G>T] + [-714G>T] [-690C>T] + [-690C>T] | 3 (7.5) | 1 (2.5) | 4/40 (10) | 4 (3.7) | 7 (6.4) | 11/109 (10.1) |
TT | No mutations | 7 (17.5) | 5 (12.5) | 12/40 (30) | 18 (16.5) | 22 (20.2) | 40/109 (36.7) |
TC | [-786T>C] + [=] [-714G>T] + [=] [-690C>T] + [=] | 10 (25) | 4 (10) | 14/40 (35) | 18 (16.5) | 22 (20.2) | 40/109 (36.7) |
TA | [-786T>C] + [=] [-764A>G] + [=] [-690C>T] + [=] | 2 (5) | 2 (5) | 4/40 (10) | 1 (0.9) | 8 (7.3) | 9/109 (8.3) |
CA | [-764A>G] + [=] [-714G>T] + [=] [-786T>C] + [-786T>C] [-690C>T] + [-690C>T] | 2 (5) | 3 (7.5) | 5/40 (12.5) | 3 (2.7) | 4 (3.7) | 7/109 (6.4) |
AA | [-786T>C] + [-786T>C] [-764A>G] + [-764A>G] [-690C>T] + [-690C>T] | 1 (2.5) | 0 | 1/40 (2.5) | 1 (0.9) | 0 | 1/109 (0.9) |
Total | 25/40 (62.5) | 15/40 (37.5) | 40/149 (26.8) | 46/109 (42.2) | 63/109 (57.8) | 109/149 | |
SSCP | Haplotypes | PCa % | BPH % | PCa % | BPH % | ||
N | [-786T>C; -690A>G; -649G>A] | 0 | 0 | 1 | 0 | ||
T | No mutations | 56 | 53 | 61 | 59 | ||
C | [-786T>C; -714G>T; -690C>T] | 32 | 30 | 31 | 32 | ||
A | [-786T>C; -764A>G; -690C>T] | 12 | 17 | 7 | 9 | ||