The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor

BMC Cancer

Table 2 Association of Cyclin D1 870 G>A (rs603965) Polymorphism with Endometrial Cancer Risk

Genotype	Cases n (%)	Controls n (%)	χ²	OR (95% CI) and p value
GG	49 (25.7)	93 (32.1)	p = 0.161	1.00 (reference)
				1.262 (0.771–2.066)_adj#	p = 0.355
				1.256 (0.815–1.938)	p = 0.302
AA	48 (25.1)	55 (19.0)		1.692 (0.939–3.049)_adj#	p = 0.080
				1.656 (0.989–2.784)	p = 0.057
GA+AA	142 (74.3)	197 (67.9)	p = 0.131^†	1.383 (0.869–2.201)_adj#	p = 0.172
				1.368 (0.910–2.057)	p = 0.132
GG+GA	143 (74.9)	235 (81.0)	p = 0.107^‡	1.458 (0.889–2.393)_adj#	p = 0.135
				1.434 (0.924–2.226)	p = 0.108

Note: Minor Allele Frequency (MAF) 0.317.
# OR_adj: Adjusted for BMI, HBP, diabetes, HT, personal history of cancer, smoking and alcohol use.
† p value: Wild type genotype (GG) compared to combination of heterozygous and homozygous variant genotypes (GA+AA).
‡ p value: Homozygous variant genotype (AA) compared to combination of wild type and heterozygous genotypes (GG+GA).

ISSN: 1471-2407