Table 2 The genes that significantly differed between survivors and deceased patients.

ADA

NM_000022

adenosine deaminase

Higher

adenosine deaminase activity, hydrolase activity

1/1

BCAT1

NM_005504

branched chain aminotransferase 1, cytosolic

Higher

branched-chain-amino-acid transaminase activity, catalytic activity, transferase activity

1/1

C9orf164

NM_006378

chromosome 9 open reading frame 164

Higher

0/0

CCDC99

NM_017785

coiled-coil domain containing 99

Higher

1/0

CCNB1IP1

NM_182849

cyclin B1 interacting protein 1

Higher

ligase activity, metal ion binding

1/1

COMMD9

NM_014186

COMM domain containing 9

Higher

0/1

CPS1

NM_001875

carbamoyl-phosphate synthetase 1, mitochondrial

Higher

ATP binding, carbamoyl-phosphate synthase (ammonia) activity, ligase activity, nucleotide binding, protein binding

1/2

E2F2

NM_004091

E2F transcription factor 2

Higher

protein binding, transcription factor activity

1/1

F2

NM_000506

coagulation factor II (thrombin)

Higher

calcium ion binding, receptor binding, thrombin activity, thrombin activity

1/1

GGH

NM_003878

gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)

Higher

exopeptidase activity, hydrolase activity

1/1

GIT2

NM_014776

G protein-coupled receptor kinase interactor 2

Higher

GTPase activator activity, metal ion binding

2/2

GNG10

NM_004125

guanine nucleotide binding protein (G protein), gamma 10

Higher

GTPase activity, heat shock protein binding, signal transducer activity

1/0

HPS5

NM_007216

Hermansky-Pudlak syndrome 5

Higher

protein binding

1/1

KCNAB2

NM_003636

potassium voltage-gated channel, shaker-related subfamily, beta member 2

Higher

ion channel activity, oxidoreductase activity, potassium channel regulator activity, potassium ion binding

1/0

MGC13057

NM_032321

hypothetical protein MGC13057

Higher

0/0

MRTO4

NM_016183

mRNA turnover 4 homolog (S. cerevisiae)

Higher

0/1

MTERF

NM_006980

mitochondrial transcription termination factor

Higher

DNA binding, double-stranded DNA binding, transcription termination factor activity

1/1

MYO1G

NM_033054

myosin IG

Higher

ATP binding, motor activity

0/0

NPM3

NM_006993

nucleophosmin/nucleoplasmin, 3

Higher

nucleic acid binding

1/0

PIR

NM_003662

pirin (iron-binding nuclear protein)

Higher

metal ion binding, transcription cofactor activity

1/1

PLEKHM2

XM_290944

pleckstrin homology domain containing, family M (with RUN domain) member 2

Higher

oxidoreductase activity

0/0

PRPS1L1

NM_175886

phosphoribosyl pyrophosphate synthetase 1-like 1

Higher

kinase activity, lipoate-protein ligase B activity, magnesium ion binding, ribose phosphate diphosphokinase activity, transferase activity

0/1

RAB23

NM_183227

RAB23, member RAS oncogene family

Higher

GTP binding, nucleotide binding

1/1

RCN1

NM_002901

reticulocalbin 1, EF-hand calcium binding domain

Higher

calcium ion binding

0/0

RP5-1077B9.4

NM_021933

invasion inhibitory protein 45

Higher

1/0

SALL4

NM_020436

sal-like 4 (Drosophila)

Higher

DNA binding, metal ion binding, nucleic acid binding, protein binding

0/0

SERPINB9

NM_004155

serpin peptidase inhibitor, clade B (ovalbumin), member 9

Higher

protein binding, serine-type endopeptidase inhibitor activity

1/2

SLC35B4

NM_032826

solute carrier family 35, member B4

Higher

UDP-N-acetylglucosamine transporter activity, UDP-xylose transporter activity, nucleotide-sugar transporter activity, sugar porter activity

0/0

SPATA5

NM_145207

spermatogenesis associated 5

Higher

ATP binding, nucleoside-triphosphatase activity, nucleotide binding

0/0

TM4SF5

NM_003963

transmembrane 4 L six family member 5

Higher

1/0

TRPV2

NM_016113

transient receptor potential cation channel, subfamily V, member 2

Higher

calcium ion binding, ion channel activity

2/0

B

Gene Symbol

Accesion number

Gene Name

Expression deceased vs 10-year survivors

Gene Ontology, Function

van't Veer/Wang

ARFIP1

NM_001025595

ADP-ribosylation factor interacting protein 1 (arfaptin 1)

Lower

identical protein binding

1/0

ARSD

NM_001669

arylsulfatase D

Lower

arylsulfatase activity, calcium ion binding, hydrolase activity

2/2

C1orf43

NM_015449

chromosome 1 open reading frame 43

Lower

1/0

C4orf26

NM_178497

chromosome 4 open reading frame 26

Lower

0/0

CCDC24

NM_152499

coiled-coil domain containing 24

Lower

0/0

CUL7

NM_014780

cullin 7

Lower

protein binding

1/2

EDEM3

NM_025191

ER degradation enhancer, mannosidase alpha-like 3

Lower

calcium ion binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, peptidase activity

0/0

FAAH

NM_001441

fatty acid amide hydrolase

Lower

amidase activity, hydrolase activity, receptor binding

2/1

FXYD3

NM_005971

FXYD domain containing ion transport regulator 3

Lower

chloride ion binding, ion channel activity

1/0

GOLT1A

NM_198447

golgi transport 1 homolog A (S. cerevisiae)

Lower

1/0

NEIL1

NM_024608

nei endonuclease VIII-like 1 (E. coli)

Lower

DNA N-glycosylase activity, damaged DNA binding, hydrolase activity, acting on glycosyl bonds, lyase activity, oxidized purine base lesion DNA N-glycosylase activity, zinc ion binding

1/0

OR7E91P

NR_002185

olfactory receptor, family 7, subfamily E, member 91 pseudogene

Lower

receptor activity

0/0

PHLDA3

NM_012396

pleckstrin homology-like domain, family A, member 3

Lower

1/0

PLEKHA6

NM_014935

pleckstrin homology domain containing, family A member 6

Lower

1/1

RORC

NM_005060

RAR-related orphan receptor C

Lower

metal ion binding, sequence-specific DNA binding, steroid hormone receptor activity, transcription factor activity

1/1

TAF5L

NM_014409

TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65 kDa

Lower

transcription factor activity

1/1

TMEM63A

NM_014698

transmembrane protein 63A

Lower

1/4

ZNF497

NM_198458

zinc finger protein 497

Lower

metal ion binding, nucleic acid binding

0/0

ZNF691

NM_015911

zinc finger protein 691

Lower

metal ion binding, nucleic acid binding

0/0

ZNF692

NM_017865

zinc finger protein 692

Lower

metal ion binding, nucleic acid binding

1/0