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Table 5 Clinicopathological and immunohistochemical parameters in relation to cytoplasmic ITIH2 immunoreactivity

From: Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: A systematic expression analysis

Variable Categorization ITIH2 immunoreactivity Tumor-related death Tumor recurrence
   n analyzable weak strong p3 n events p4 n events p4
Clinicopathological factor:           
Tumor stage1           
  pT1 46 19 27 0.875 46 7 <0.001 45 10 <0.001
  pT2 92 43 49   92 32   89 41  
  pT3 13 5 8   13 6   12 6  
  pT4 30 12 18   30 19   27 19  
Lymph node status1           
  pN0 71 30 41 0.757 71 12 <0.001 69 14 <0.001
  pN1–3 104 47 57   104 47   100 57  
Histological grade           
  low grade (G1 – G2) 100 40 60 1.000 100 26 <0.001 95 33 <0.001
  high grade (G3) 80 38 42   80 38   78 42  
Histological type           
  ductal 145 61 84 0.915 145 51 0.772 142 65 0.371
  lobular 13 5 8   13 6   11 4  
  other 19 9 10   19 6   17 5  
Immunohistochemistry (IHC):           
Estrogen receptor status  
  negative (IRS2 0–2) 49 30 19 0.001 49 21 0.080 49 25 0.096
  positive (IRS 3–12) 97 31 66   97 29   93 33  
Progesterone receptor status           
  negative (IRS2 0–2) 107 44 63 0.862 107 48 0.001 101 50 0.008
  positive (IRS 3–12) 49 21 28   49 9   49 13  
HER2 expression status           
  negative 120 53 67 0.190 120 33 <0.001 113 43 0.007
  positive 38 12 26   38 22   38 22  
  1. P-values according to Fisher's exact test (two-sided) were calculated for significance of correlation between clinicopathological and immunohistochemical parameters in relation to cytoplasmatic ITIH2 immunoreactivity. Furthermore, univariate analysis of factors regarding tumor-specific survival and recurrence-free survival was performed with significance calculated by log rank test (two-sided).
  2. 1According to UICC: TNM Classification of Malignant Tumours (2002) [65]. 2IRS = Immunoreactivity score according to Remmele and Stegner (1987) [47]. 3Fisher's exact test (two-sided). 4Log-rank test (two-sided). Bold face representing significant data (p < 0.05).