Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: A systematic expression analysis

Table 4 Frequent loss of ITIH expression in multiple human solid tumors.

Tissue	n	ITIH1 regulation (%)		ITIH2 regulation (%)		ITIH3 regulation (%)		ITIH4 regulation (%)		ITIH5 regulation (%)		AMBP regulation (%)		TNFAIP6 regulation (%)
		up	down	up	down	up	down	up	down	up	down	up	down	up	down
Breast	50	2	6	2	70	9	51	6	16	6	52	4	10	6	35
Uterus	42	0	10	12	26	5	62	7	29	5	24	0	7	21	13
Colon	35	11	9	11	43	9	67	9	54	3	40	3	0	31	31
Stomach	27	7	19	30	56	12	38	4	63	15	19	0	37	48	12
Ovary	14	7	14	18	27	21	71	14	57	0	21	21	7	43	29
Lung	21	0	0	0	71	0	86	10	52	0	14	5	5	0	30
Kidney	20	0	35	0	70	10	35	0	95	15	0	0	90	91	0
Rectum	18	0	11	22	61	6	72	6	50	11	22	6	11	13	25
Thyroid	6	0	0	17	17	0	50	17	33	0	17	0	17	n.e.
Prostate	4	50	25	0	50	0	100	0	75	0	0	0	25	n.e.

Densitometric analysis of hybridization signals shown in Fig. 2. Percentages of deregulation (two-fold up- or down-regulation according to the well-established fold change two approach, FC2) in the given tumor entity (n.e. = not expressed). Fold changes between 0.5 and 2.0 were considered as not differentially expressed and are represented as the missing percentages to 100% in each tumor entity. Only tumor entities with four or more samples (n ≥ 4) on the CPA were considered for densitometric evaluation.