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Table 4 Frequent loss of ITIH expression in multiple human solid tumors.

From: Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: A systematic expression analysis

Tissue n ITIH1 regulation (%) ITIH2 regulation (%) ITIH3 regulation (%) ITIH4 regulation (%) ITIH5 regulation (%) AMBP regulation (%) TNFAIP6 regulation (%)
   up down up down up down up down up down up down up down
Breast 50 2 6 2 70 9 51 6 16 6 52 4 10 6 35
Uterus 42 0 10 12 26 5 62 7 29 5 24 0 7 21 13
Colon 35 11 9 11 43 9 67 9 54 3 40 3 0 31 31
Stomach 27 7 19 30 56 12 38 4 63 15 19 0 37 48 12
Ovary 14 7 14 18 27 21 71 14 57 0 21 21 7 43 29
Lung 21 0 0 0 71 0 86 10 52 0 14 5 5 0 30
Kidney 20 0 35 0 70 10 35 0 95 15 0 0 90 91 0
Rectum 18 0 11 22 61 6 72 6 50 11 22 6 11 13 25
Thyroid 6 0 0 17 17 0 50 17 33 0 17 0 17 n.e.
Prostate 4 50 25 0 50 0 100 0 75 0 0 0 25 n.e.
  1. Densitometric analysis of hybridization signals shown in Fig. 2. Percentages of deregulation (two-fold up- or down-regulation according to the well-established fold change two approach, FC2) in the given tumor entity (n.e. = not expressed). Fold changes between 0.5 and 2.0 were considered as not differentially expressed and are represented as the missing percentages to 100% in each tumor entity. Only tumor entities with four or more samples (n ≥ 4) on the CPA were considered for densitometric evaluation.