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Table 3 ORs and 95% CIs for ICC HPV-16EP or AA positive according to HLA.

From: Interaction between polymorphisms of the Human Leukocyte Antigen and HPV-16 Variants on the risk of invasive cervical cancer

 

Controls

AA Cases

EP Cases

HLA

C/N

C/N

Crude

Adjusted

C/N

Crude

Adjusted

 

Controls

Cases

OR

OR (95% CI)

Cases

OR

OR (95% CI)

 

n = 257

n = 37

  

n = 24

  

DQA1

       

*0101/04

79/178

5/32

0.35

0.34(0.12–0.93)

9/15

1.35

1.31 (0.53–3.25)

*0102

80/177

10/27

0.82

0.82(0.37–1.83)

12/12

2.21

2.32 (0.96–5.62)

DQB1

       

*0301

78/179

9/28

0.74

0.74(0.32–1.70)

8/16

1.15

1.08 (0.42–2.75)

   *05

95/162

5/32

0.27

0.27(0.10–0.75)

10/14

1.22

1.29 (0.53–3.14)

*0501

71/186

4/33

0.32

0.30 (0.10–0.92)

9/15

1.57

1.56 (0.63–3.89)

   *06

87/170

16/21

1.49

1.49 (0.72–3.08)

12/12

1.95

2.02 (0.84–4.88)

*0602

44/213

9/28

1.56

1.45 (0.62–3.39)

8/16

2.42

2.13 (0.83–5.50)

DRB1

       

   *01

52/205

4/33

0.48

0.45 (0.15–1.37)

7/17

1.62

1.51 (0.57–4.03)

*0102

29/228

1/36

0.22

0.18 (0.02–1.44)

6/18

2.62

2.18 (0.75–6.29)

   *04

74/183

10/27

0.92

0.94 (0.42–2.09)

3/21

0.35

0.34 (0.10–1.21)

   *13

61/196

9/28

1.03

1.21 (0.52–2.78)

5/19

0.85

1.09 (0.37–3.16)

*1302

27/230

0/37

0.00

 

3/21

1.22

1.62 (0.42–6.16)

   *15

34/223

10/27

2.43

2.34 (1.00–5.46)

8/16

3.28

2.99 (1.13–7.86)

*1503

14/243

5/32

2.71

2.62 (0.83–8.27)

4/20

3.47

3.75 (0.99–12.42)

DRB1-DQB1 haplotypes

       

   0102-0501

29/228

1/36

0.22

0.18 (0.02–1.44)

6/18

2.62

2.18 (0.75–6.29)

   15-0602

33/224

8/29

1.87

1.84 (0.75–4.53)

8/16

3.39

3.08 (1.17–8.14)

   1503-0602

14/243

5/32

2.71

2.62 (0.83–8.27)

4/20

3.47

3.50 (0.99–12.42)

   08041-0301

5/252

0/27

  

2/22

4.58

3.59 (0.48–27.13)

   09012-0201/02

3/254

1/36

2.35

2.62 (0.25–27.79)

1/23

3.68

5.00 (0.47–53.36)