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Table 5 Accuracy estimatives from MSP for RARB and RASSF1A genes observed in primary and/or previous recurrence of urinary bladder carcinoma and respective washout.

From: DNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection

Gene

Accuracy patterns (%)

 

Sensitivity

Specificity

PPV

NPV

p(1)

Sediment of washout cells

RARB

1/6 (16.7)

13/14 (92.8)

1/2 (50.0)

13/18 (72.2)

0.521

RASSF1A

0/4 (0.00)

5/10 (50.0)

0/5 (0.00)

5/9 (55.5)

0.220

Fixed and paraffin-embedded bladder cancer tissue

RARB

5/6 (83.3)

7/14 (50.0)

5/12 (41.6)

7/8 (87.5)

0.324

RASSF1A

4/4 (100.0)

4/7 (57.1)

4/7 (57.1)

4/4 (100.0)

0.193

  1. Cytology results were used as reference to detect the recurrence.
  2. (1) Fisher's Exact test (α = 0.05); PPV – positive predictive value; NPV – negative predictive value