Figure 2
From: Potential value of PTEN in predicting cetuximab response in colorectal cancer: An exploratory study
Representative sections of gene expression by FISH. a. High amplification of EGFR gene (red signals) in all tumor cells; b. Aneuploidy of chromosome 7 (green signals) accompanied by extra copies of EGFR gene (arrows). Five copies of chromosome 7 in one tumor cell are also visible (arrowhead); c. & d. Trisomy chromosome 10 (green signals) and extra copies of PTEN gene (red signals), (arrowhead), PTEN gene homozygous deletion (stealth arrow), heterozygous deletion (arrow).