Table 3 Association between ERG and TMPRSS2 SNP genotypes and TMPRSS2-ERG fusion status
Fusion Status | ||||||
|---|---|---|---|---|---|---|
Gene | SNP | Genotype | Negative | Positive | P value | |
ERG | rs1571704 | GG | 66 (84.6) | 43 (89.6) | ||
GT/TT | 12 (15.4) | 5 (10.4) | 0.59 | |||
rs1892570 | CC | 64 (81.0) | 44 (91.7) | |||
CT/TT | 15 (19.0) | 4 (8.3) | 0.13 | |||
rs2068967 | GG | 24 (30.4) | 15 (31.3) | |||
GA/AA | 55 (69.6) | 33 (68.7) | 0.10 | |||
rs2836370 | TT | 18 (22.5) | 12 (25.5) | |||
TC/CC | 62 (77.5) | 35 (74.5) | 0.83 | |||
TMPRSS2 | rs12329760 | CC | 53 (68.0) | 26 (53.1) | ||
CT/TT | 25 (32.0) | 23 (46.9) | 0.13 | |||
Negative | Translocation | Deletion | ||||
ERG | rs1571704 | GG | 66 (84.6) | 18 (85.7) | 25 (92.6) | |
GT/TT | 12 (15.4) | 3 (14.3) | 2 (7.4) | 0.66 | ||
rs1892570 | CC | 64 (81.0) | 19 (90.5) | 25 (92.6) | ||
CT/TT | 15 (19.0) | 2 (9.5) | 2 (7.4) | 0.33 | ||
rs2068967 | GG | 24 (30.4) | 9 (42.8) | 6 (22.2) | ||
GA/AA | 55 (69.6) | 12 (57.2) | 21 (77.8) | 0.31 | ||
rs2836370 | TT | 18 (22.5) | 5 (23.8) | 7 (26.9) | ||
TC/CC | 62 (77.5) | 16 (76.2) | 19 (73.1) | 0.91 | ||
TMPRSS2 | rs12329760 | CC | 53 (68.0) | 8 (38.1) | 18 (64.3) | |
CT/TT | 25 (32.0) | 13 (61.9) | 10 (35.7) | 0.05 | ||
Negative | Single | Multiple | ||||
ERG | rs1571704 | GG | 66 (84.6) | 40 (93.0) | 3 (60.0) | |
GT/TT | 12 (15.4) | 3 (7.0) | 2 (40.0) | 0.09 | ||
rs1892570 | CC | 64 (81.0) | 40 (93.0) | 4 (80.0) | ||
CT/TT | 15 (19.0) | 3 (7.0) | 1 (20.0) | 0.15 | ||
rs2068967 | GG | 24 (30.4) | 12 (27.9) | 3 (60.0) | ||
GA/AA | 55 (69.6) | 31 (72.1) | 2 (40.0) | 0.36 | ||
rs2836370 | TT | 18 (22.5) | 11 (26.2) | 1 (20.0) | ||
TC/CC | 62 (77.5) | 31 (73.8) | 4 (80.0) | 0.86 | ||
TMPRSS2 | rs12329760 | CC | 53 (68.0) | 25 (58.1) | 1 (16.7) | |
CT/TT | 25 (32.0) | 18 (41.9) | 5 (83.3) | 0.03 | ||