Figure 5
From: Imagable 4T1 model for the study of late stage breast cancer
Metastasis to lungs, kidneys, adrenals and liver. (A) Lung at 3 weeks showing metastases adjacent to blood vessels. (B) Tumor cells in a major vessel of the kidney at week 6. Note infiltration of tumor cells into kidney parenchyma (arrowhead, left panel). (C) Tumor-laden adrenal gland at 6 weeks with multiple spherically-shaped metastases. (D) Large metastasis on the surface of the liver at week 6. Note abnormal appearance of liver parenchyma and high levels of leukocytes in parenchyma (arrowheads, right panel) and sinusoids (arrows, right panel). Specimens were obtained from the experiment described in Figure 3.