Pathways involved in metastatic phenotype of 4T1. Pathways shown are based on known Kegg pathways with modifications based on recent literature relating 4T1 phenotype genes to these pathways. Red and blue boxes represent genes that are up-regulated or down-regulated by > 2-fold, respectively. Red arrows represent chemotaxis. Numbers outside the boxes give the higher of the two ratios for expression in 4T1 relative to the non-metastatic 67NR and 168FARN lines.