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Table 2 HT-29 and Caco-2 semiquantitative EGFR immunostaining evaluation (FS Cod)

From: Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell lines

 

HT-29

Caco-2

 

Membrane

Cytoplasm

Membrane

Cytoplasm

NT

Intermediate

Intermediate

Low

Low

E

Negative

Intermediate

Negative

Low

Cx5

Intermediate

Intermediate

Low

Low

Cx5 + E

Negative

Intermediate

Negative

Low

Cx10

Intermediate

Low

Negative

Low

Cx10 + E

Negative

Intermediate

Negative

Low

Gb

Intermediate

Intermediate

Low

Low

Gb + E

Negative

Intermediate

Negative

Low

  1. Membrane = Membrane immunostaining Histoscore; Cytoplasm = Cytoplasmic immunostaining Histoscore; FS Cod = Final Score coded according to cut-off values (see Material and Methods).
  2. NT = untreated; E = Epidermal growth factor 10 nmol/L; Cx5 = cetuximab 5 nmol/L;
  3. Cx10 = cetuximab 10 nmol/L; Gb = gefitinib 1 μmol/L; Cx5 + E = cetuximab 5 nmol/L + Epidermal growth factor 10 nmol/L; Cx10 + E = cetuximab 10 nmol/L + Epidermal growth factor 10 nmol/L;
  4. Gb + E = gefitinib 1 μmol/L + Epidermal growth factor 10 nmol/L.