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Table 3 Median GDMI of normal non-disease, normal disease and the paired tumors for different methyl-sensitive restriction enzymes

From: A high-throughput and sensitive method to measure Global DNA Methylation: Application in Lung Cancer

A

   

Median GDMI of normal non-disease, normal disease and the paired tumors for different methyl-sensitive restriction enzymes.

Sample Type

HinP1 I

HpyCH4 IV

Hpa II

Normal Non-Disease

0.163

0.304

0.293

Normal Disease

0.197

0.368

0.321

Tumor

0.216

0.427

0.379

B

   

Non-parametric tests of normal disease versus paired tumor, normal non-disease versus normal disease, and normal non-disease versus tumor for each of the methyl-sensitive restriction enzymes.

Comparisons

HinP1 I

HpyCH4 IV

Hpa II

Normal Disease vs Tumor

0.068*

0.201

0.064*

Normal Non-Disease vs Normal Disease

0.483

0.129

0.039**

Normal Non-Disease vs Tumor

0.005**

0.054*

0.004**

  1. Numbers in bold with asterisks indicate statistical significance of Wilcoxon/Kruskal-Wallis tests with threshold of p <= 0.05 (**) or p <= 0.10 (*).