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Figure 7 | BMC Cancer

Figure 7

From: Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5)

Figure 7

Compilation of functionally important bindings sites in the three LM-332 promoters. This scheme shows a summary of results reflecting the complexity of promoter regulation of LM-322. Indicated in the three promoters are the binding sites with significant importance for basal promoter activity "B"; for Smad4 dependent constitutive activity "SC" and for Smad4 dependent TGFβ induction "ST". In addition, binding of Smad4 as confirmed with ChIP analysis is indicated on top of the promoters.

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