Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1gene in Sri Lankan breast cancer patients and at risk individuals

Table 1 Characteristics of patients and at risk individuals

	Familial breast cancer patients (N = 66)	Sporadic breast cancer patients (N = 64)	At risk Individuals (N = 70)
Age (years) at diagnosis (patients)/sample collection (at risk individuals)
Mean ± SD	46.97+9.05	47.37+10.06	40.51+12.01
≤ 40	18	20	33
> 40	48	44	37
Number of family members with breast cancer
N = 0	0	64	0
N = 1	44 (1^st: 18, 2^nd: 26)	0	28
N = 2	19 (1^st: 5, 2^nd: 11, 1^st & 2^nd both: 3)	0	18
N = 3	03 (1^st and 2^nd)	0	24
Number of family members with other cancers*
N = 1	16	0	17
N = 2	07	0	24
N = 3	01	0	01
N = 4	01	0	0
Ethnicity
Muslim	02	03	01
Sinhalese	62	58	68
Tamil	02	03	01

* colorectal, lung, oral, ovarian, thyroid, uterine cancers 1^st: 1^st degree relative, 2^nd: 2^nd degree relative affected with breast cancer

ISSN: 1471-2407