Molecular detection (k-ras) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer?

Table 1 Clinical and pathologic parameters in patients with positive and negative k-ras mutations.

	k-ras marker Positive	k-ras marker Negative	P
Gender male/female	12/7	127/91	n.s
Age mean ± st.dv	65,8 ± 9.3	64.8 ± 11.8	n.s
Operation technique
APR	7	88	n.s
LAR	6	79
Hartmann's procedure	3	41
EkspI.lap	2	4
Tumour reduction	1	6
Primary rectal cancer	13	176	n.s
Locally recurrent rectal cancer	6	42
pT0-T1	0	19	n.s
pT2	2	21
pT3	9	105
pTx	8	47
N0	6	125	p = 0.03
N1/N2	6	64
NX	7	24
M0	15	180	n.s
M1	4	38
R0	12	155	p = 0.002
R1	3	56
R2	4	7
Distant metastasis during follow-up	4	70	n.s
Local recurrence during follow-up	7	31	n.s
Tumour perforation	5	37	n.s

APR: Abdominoperineal resection
LAR: Low anterior resection
EkspI. Lap: Explorative laparotomy
Local recurrence in this study means locally recurrent in the pelvis.
Distant metastasis in this study is distant metastasis or peritoneal carsinomatose.

ISSN: 1471-2407